Pulmonary fate of histamine, isoproterenol, physalaemin, and substance P.
Pulmonary fate of histamine, isoproterenol, physalaemin, and substance P.
复制标题
组胺、异丙肾上腺素、酸浆素和 P 物质的肺部归宿。
DOI：
--
复制
发表时间：
1970
影响因子：
2.1
通讯作者：
P. Biron
中科院分区：
文献类型：
--
作者：
J. Boileau;L. Campeau;P. Biron
通过一种基于全身降压反应的测定方法，研究了四种血管扩张剂在单次通过肺循环期间的生物失活。异丙肾上腺素在接受心导管术的人和麻醉的正常狗身上进行了测试。在麻醉的正常大鼠和狗身上检测组胺和普鲁米林，在大鼠身上检测P物质。这四种血管扩张剂的失活程度要么可以忽略不计，要么很小，很少超过15%。结论是，肺不是从循环中清除这些物质的重要部位。肺中组胺的轻微失活表明，组胺可能起到某种“循环”荷尔蒙的作用。与缓激肽不同的是，“速激肽”的菲沙拉明和P物质几乎不会发生肺失活。异丙肾上腺素没有肺部失活，这解释了吸入给药时它进入体循环的原因。
The biological inactivation of four vasodilator agents during a single passage through the pulmonary circulation was studied by means of an assay based on systemic depressor responses. Isoproterenol was tested in humans undergoing cardiac catheterization and in anesthetized normal dogs. Histamine and physalaemin were tested in anesthetized normal rats and dogs; substance P was tested in rats. The degree of inactivation of these four vasodilator agents was either negligible or small, rarely exceeding 15%. It is concluded that the lung is not an important site for the removal of these substances from the circulation. The small degree of pulmonary inactivation of histamine suggests that it could play some role as a "circulating" hormone. Unlike bradykinin, the "tachykinins" physalaemin and substance P undergo little pulmonary inactivation. The absence of lung inactivation of isoproterenol explains its entry into the systemic circulation when given by inhalation.