Origin of developmental precursors dictates the pathophysiologic role of cardiac fibroblasts.
Origin of developmental precursors dictates the pathophysiologic role of cardiac fibroblasts.
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DOI：
10.1007/s12265-012-9402-7
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发表时间：
2012-12
影响因子：
3.4
通讯作者：
Entman, Mark L.
中科院分区：
文献类型：
--
作者：
Crawford, Jeffrey R.;Haudek, Sandra B.;Cieslik, Katarzyna A.;Trial, JoAnn;Entman, Mark L.
关键词：
心脏中的成纤维细胞在细胞外基质的分泌和调节中发挥关键作用，细胞外基质对于其机械功能所需的最佳细胞结构和机械稳定性至关重要。成纤维细胞也密切参与心脏损伤的适应性和非适应性反应。成纤维细胞提供细胞外基质的加工，并且作为肌成纤维细胞，负责交联该基质以在心肌梗死后形成机械稳定的瘢痕。相比之下，在心力衰竭期间，成纤维细胞分泌细胞外基质，其表现为过度的间质纤维化，其可能机械地限制心脏功能并扭曲心脏结构（不良重塑）。本文综述了成纤维细胞介导的瘢痕形成和成纤维细胞介导的间质纤维化产生于不同的细胞前体，并响应于不同的autocoidal信号级联的假说。我们证明，产生瘢痕的成纤维细胞来自内源性间充质干细胞，而那些介导不良重塑的是骨髓来源，代表免疫炎症失调。
Fibroblasts in the heart play a critical function in the secretion and modulation of extracellular matrix critical for optimal cellular architecture and mechanical stability required for its mechanical function. Fibroblasts are also intimately involved in both adaptive and nonadaptive responses to cardiac injury. Fibroblasts provide the elaboration of extracellular matrix and, as myofibroblasts, are responsible for cross-linking this matrix to form a mechanically stable scar after myocardial infarction. By contrast, during heart failure, fibroblasts secrete extracellular matrix, which manifests itself as excessive interstitial fibrosis that may mechanically limit cardiac function and distort cardiac architecture (adverse remodeling). This review examines the hypothesis that fibroblasts mediating scar formation and fibroblasts mediating interstitial fibrosis arise from different cellular precursors and in response to different autocoidal signaling cascades. We demonstrate that fibroblasts which generate scars arise from endogenous mesenchymal stem cells, whereas those mediating adverse remodeling are of myeloid origin and represent immunoinflammatory dysregulation.
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影响因子：
20.1
作者：
JALIL, JE;JANICKI, JS;WEBER, KT
通讯作者：
WEBER, KT
DOI：
10.1152/ajpheart.00206.2001
发表时间：
2002-02-01
影响因子：
4.8
作者：
Gould, KE;Taffet, GE;Entman, ML
通讯作者：
Entman, ML
影响因子：
6
作者：
Lakshminarayanan, V;Lewallen, M;Entman, ML
通讯作者：
Entman, ML
影响因子：
37.8
作者：
Kumar, AG;Ballantyne, CM;Entman, ML
通讯作者：
Entman, ML
影响因子：
4.8
作者：
Ingram, JL;Rice, AB;Bonner, JC
通讯作者：
Bonner, JC