Noninvasive 4D pressure difference mapping derived from 4D flow MRI in patients with repaired aortic coarctation: comparison with young healthy volunteers
Noninvasive 4D pressure difference mapping derived from 4D flow MRI in patients with repaired aortic coarctation: comparison with young healthy volunteers
复制标题
主动脉缩窄修复患者的 4D 血流 MRI 衍生的无创 4D 压差图：与年轻健康志愿者的比较
DOI：
10.1007/s10554-015-0604-3
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
S. Ley
中科院分区：
文献类型：
--
作者：
F. Rengier;M. Delles;J. Eichhorn;Y. Azad;H. von Tengg-Kobligk;J. Ley- Zaporozhan;R. Dillmann;H.U. Kauczor;R. Unterhinninghofen;S. Ley
使用时间分辨速度编码三维相位对比磁共振成像（4D flow MRI）和衍生的4D压差图，评估主动脉缩窄修复患者与年轻健康志愿者的空间和时间压力特征。以侵入性导管插入术作为金标准进行体外验证后，在1.5T下对13例主动脉缩窄修复术后无再缩的连续患者和13例健康志愿者进行了胸主动脉4D flow MRI。使用内部开发的处理软件，基于Navier-Stokes方程计算4D压差图。由三名阅片人回顾性测量收缩中期的压差幅度、压力幅度的最大斜率和空间压力范围，并由一名阅片人测量两次，以评估观察者间和观察者内的一致性。在体外，来自4D流动MRI的压力差显示出与侵入性导管测量的良好一致性。在体内，与志愿者相比，患者主动脉弓、近端降主动脉和远端降主动脉的压差幅度、压差幅度的最大斜率和收缩中期的空间压力范围显著增加（p< 0.05）。最大的差异发生在降主动脉近端，患者与志愿者的三个参数值分别为19.7 ± 7.5与10.0 ± 2.0（p< 0.001），10.9 ± 10.4与1.9 ± 0.4（p= 0.002）和8.7 ± 6.3与1.6 ± 0.9（p< 0.001）。观察者间和观察者内的一致性非常好（p< 0.001）。来自4D flow MRI的无创4D压差标测能够检测腔内主动脉压的变化，并显示修复主动脉缩窄患者的显著空间和时间变化。
To assess spatial and temporal pressure characteristics in patients with repaired aortic coarctation compared to young healthy volunteers using time-resolved velocity-encoded three-dimensional phase-contrast magnetic resonance imaging (4D flow MRI) and derived 4D pressure difference maps. After in vitro validation against invasive catheterization as gold standard, 4D flow MRI of the thoracic aorta was performed at 1.5T in 13 consecutive patients after aortic coarctation repair without recoarctation and 13 healthy volunteers. Using in-house developed processing software, 4D pressure difference maps were computed based on the Navier–Stokes equation. Pressure difference amplitudes, maximum slope of pressure amplitudes and spatial pressure range at mid systole were retrospectively measured by three readers, and twice by one reader to assess inter- and intraobserver agreement. In vitro, pressure differences derived from 4D flow MRI showed excellent agreement to invasive catheter measurements. In vivo, pressure difference amplitudes, maximum slope of pressure difference amplitudes and spatial pressure range at mid systole were significantly increased in patients compared to volunteers in the aortic arch, the proximal descending and the distal descending thoracic aorta (p< 0.05). Greatest differences occurred in the proximal descending aorta with values of the three parameters for patients versus volunteers being 19.7 ± 7.5 versus 10.0 ± 2.0 (p< 0.001), 10.9 ± 10.4 versus 1.9 ± 0.4 (p= 0.002), and 8.7 ± 6.3 versus 1.6 ± 0.9 (p< 0.001). Inter- and intraobserver agreements were excellent (p< 0.001). Noninvasive 4D pressure difference mapping derived from 4D flow MRI enables detection of altered intraluminal aortic pressures and showed significant spatial and temporal changes in patients with repaired aortic coarctation.
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影响因子：
2.4
作者：
Rengier, Fabian;Delles, Michael;Ley, Sebastian
通讯作者：
Ley, Sebastian
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影响因子：
5.5
作者：
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通讯作者：
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影响因子：
37.8
作者：
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通讯作者：
J. Deanfield
影响因子：
24
作者：
Oliver, JM;Gallego, P;Mesa, JM
通讯作者：
Mesa, JM
使用矢量流信息提取相衬 MR 图像中的血管中心线
DOI：
--
发表时间：
2012
期刊：
Medical Imaging
影响因子：
--
作者：
Yoo;S. Ley;R. Dillmann;R. Unterhinninghofen
通讯作者：
R. Unterhinninghofen