Molecular insights into stress erythropoiesis
Molecular insights into stress erythropoiesis
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DOI：
10.1097/moh.0b013e3280de2bf1
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发表时间：
2007-05-01
影响因子：
3.2
通讯作者：
Socolovsky, Merav
中科院分区：
文献类型：
--
作者：
Socolovsky, Merav
综述的目的：除了其在基线红细胞生成中的重要作用外，激素促红细胞生成素还驱动对缺氧应激的红细胞生成反应。应激红细胞生成机制的理解将有利于多个临床设置，并可能有助于理解leukemogenesis.Recent findings-谱的祖细胞靶向的促红细胞生成素受体是更广泛的压力过程中比基线红细胞生成。此外，在应激期间，对促红细胞生成素受体信号传导的要求更严格。然而，促红细胞生成素受体信号转导主要在体外研究，其中很难将信号转导事件与红细胞稳态的应激依赖性变化联系起来。在这里，我们回顾了流式细胞术的进展，允许识别和造血组织中的小鼠红系前体细胞的研究，因为它们在体内响应应力。死亡受体Fas和其配体FasL由早期脾成红细胞共表达，抑制成红细胞存活和红细胞生成率。在应激期间，促红细胞生成素受体信号转导下调成红细胞Fas和FasL，从而增加erythropoietic rate.Summary促红细胞生成率至少部分通过促红细胞生成素受体介导的脾早期成红细胞存活来调节。未来的研究将描绘多种抗凋亡途径，可能激活的促红细胞生成素受体，相互作用，以产生显着的动态范围的红细胞生成。
Purpose of review In addition to its essential role in baseline erythropoiesis, the hormone erythropoietin drives the erythropoietic response to hypoxic stress. A mechanistic understanding of stress erythropoiesis would benefit multiple clinical settings, and may aid in understanding leukemogenesis.Recent findings The spectrum of progenitors targeted by the erythropoietin receptor is broader during stress than during baseline erythropoiesis. Further, the requirement for erythropoietin receptor signaling is more stringent during stress. However, erythropoietin receptor signaling has been mostly studied in vitro, where it is difficult to relate signaling events to stress-dependent changes in erythroid homeostasis. Here we review advances in flow cytometry that allow the identification and study of murine erythroid precursors in hematopoietic tissue as they are responding to stress in vivo. The death receptor Fas and its ligand, FasL, are coexpressed by early splenic erythroblasts, suppressing erythroblast survival and erythropoietic rate. During stress, erythropoietin receptor signaling downregulates erythroblast Fas and FasL, consequently increasing erythropoietic rate.Summary Erythropoietic rate is regulated at least in part through the erythropoietin receptor-mediated survival of splenic early erythroblasts. Future research will delineate how multiple antiapoptotic pathways, potentially activated by the erythropoietin receptor, interact to produce the remarkable dynamic range of erythropoiesis.