Initiation of the propagated disturbance
Initiation of the propagated disturbance
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DOI：
10.1098/rspb.1937.0083
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发表时间：
1937-11-01
期刊：
影响因子：
--
通讯作者：
Rushton, WAH
中科院分区：
文献类型：
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作者：
Rushton, WAH
长期以来，人们一直认为，传播的机制是前进的动作势波对前方的非活动区的刺激。尽管这一理论看似合理，但只有在过去一年内才公布的证据才使这一问题毋庸置疑。Blair和Erlanger(1936b)通过用钙或阳极极化阻断单个脉冲获得了提示性证据。他们发现，这种被阻止的脉冲留下了一种短暂的导电性增强状态，从而允许第二次脉冲传播。霍奇金(1937)独立地更详细地研究了这种增强的性质。他用冷或压力来阻断第一个脉冲，并发现阻断另一侧阈值的降低与动作电流的传播具有相同的时空分布。此外，动作电流扩展具有与从外部电路施加的亚阈值电流相同的时空分布，并且被安排成具有与动作电位波相同的时间过程。
It has long been supposed that the mechanism of propagation is the stimulation of the inactive region just in front, by the advancing actionpotential wave. Plausible as is this theory, it is only within the last year that evidence has been published which puts the matter beyond doubt. Blair and Erlanger (1936b) obtained suggestive evidence by blocking a single impulse with calcium or anodal polarization. They found that this blocked impulse left a transitory state of enhanced conductivity which allowed a second impulse to be propagated. The nature of this enhancement was studied independently and in greater detail by Hodgkin (1937). He used cold or pressure to block the first impulse, and found that the lowering of threshold on the farther side of the block had the same spatial and temporal distribution as had the spread of the action current. Moreover, the action current spread had the same space-time distribution as that of a subthreshold current applied from an external circuit, and so arranged as to have the same time course as the action-potential wave.