Prevalence of osteoporosis and factors affecting bone mineral density among postmenopausal Turkish women with type 2 diabetes
Prevalence of osteoporosis and factors affecting bone mineral density among postmenopausal Turkish women with type 2 diabetes
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DOI：
10.1016/j.jdiacomp.2007.06.004
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发表时间：
2009-01-01
影响因子：
3
通讯作者：
Ertorer, Melek Eda
中科院分区：
文献类型：
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作者：
Anaforoglu, Inan;Nar-Demirer, Ash;Ertorer, Melek Eda
目的：2型糖尿病对骨代谢的影响仍存在争议。本研究的目的是评估2型糖尿病与骨密度（BMD）之间的关系，并评估慢性糖尿病并发症与骨密度之间的可能关系。研究方法：采用双能X线骨密度仪对206例绝经后土耳其2型糖尿病妇女的腰椎、股骨和桡骨骨密度进行评估，并与61例年龄匹配的绝经后非糖尿病妇女进行比较。记录医学和生活方式特征、体重指数（BMI）、血红蛋白A（1c）水平以及微血管和大血管糖尿病并发症的状况。评估骨质疏松和骨量减少的发生率以及微血管和大血管并发症与BMD的关系。结果：两组在髋关节、腰椎和桡骨的BMD和T评分上没有差异。桡骨和/或腰椎和/或髋部骨质疏松症患者糖尿病持续时间较长（P=.000），年龄较大（P=.000），BMI较低（P=.000）。未发现骨量减少或骨质疏松与血红蛋白A（1c）水平、微量白蛋白尿、视网膜病变、神经病变、外周动脉疾病、脑血管事件和冠状动脉疾病之间存在相关性。在这三个部位中，臀部的BMI与BMI呈正相关（P=.000），但与年龄（P=.000）和糖尿病持续时间（P=.000）呈负相关。微量白蛋白尿与股骨颈BMD呈负相关（P= 0.042）。结论：没有证据表明2型糖尿病影响绝经后患者组的BMD。(C)2009 Elsevier Inc. All rights reserved.
Objectives: Controversy remains as to the effects of type 2 diabetes on bone metabolism. The aims of this study were to assess the association between type 2 diabetes and bone mineral density (BMD) and to evaluate the possible relationship between chronic diabetic complications and bone density. Methods: Bone mineral densities at the lumbar spine, femur, and radius in 206 postmenopausal Turkish women with type 2 diabetes were evaluated by dual-energy X-ray absorptiometry and compared with those in 61 age-matched postmenopausal nondiabetic women. Medical and lifestyle characteristics, body mass index (BMI), hemoglobin A(1c) level, and status of microvascular and macrovascular diabetic complications were recorded. Frequency of osteoporosis and that of osteopenia as well as the relationship between microvascular and macrovascular complications and BMD were evaluated. Results: The groups did not differ on BMDs and T scores at the hip, lumbar spine, and radius. Patients with radial and/or lumbar and/or hip osteoporosis had a longer duration of diabetes (P=.000), were older (P=.000), and had a lower BMI (P=.000). No correlation was found between osteopenia or osteoporosis and hemoglobin A(1c) level, presence of microalbuminuria, retinopathy, neuropathy, peripheral artery disease, cerebrovascular event, and coronary artery disease. Among the three sites, BMI at the hip was positively correlated with BMI (P=.000) but negatively correlated with age (P=.000) and duration of diabetes (P=.000). Presence of microalbuminuria revealed a negative correlation with BMD at the femoral neck (P=.042). Conclusion: There is no evidence that type 2 diabetes influenced BMD in our postmenopausal patient group. (C) 2009 Elsevier Inc. All rights reserved.