Quantitative computed tomography estimates of the mechanical properties of human vertebral trabecular bone
Quantitative computed tomography estimates of the mechanical properties of human vertebral trabecular bone
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DOI：
10.1016/s0736-0266(01)00185-1
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发表时间：
2002-07-01
影响因子：
2.8
通讯作者：
Keaveny, TM
中科院分区：
文献类型：
--
作者：
Kopperdahl, DL;Morgan, EF;Keaveny, TM
本研究的目的是报告我们的定量计算机断层扫描（QCT）密度-力学性质回归的小梁骨用于生物力学建模的人类脊柱。从32具尸体（平均+/- sd年龄= 70.1 +/- 16.8:13名女性，19名男性）中取人椎骨小梁柱状标本（T10至L4），采用QCT扫描。机械测试采用的方案是在测试的表观密度范围（0.09-0.38 g/cm(3)）内将末端伪影最小化。为了解释该数据集中每个供体存在多个标本，供体在回归模型中被视为随机效应。平均模量（319 +/- 189 MPa）更高，平均屈服应变（0.78 +/- 0.06%）低于之前报道的典型值，这是由于最小化了末端伪影误差。QCT密度与模量（n = 76）和屈服应力（r(2) = 0.90 - 0.95）呈正相关。n = 53, p < 0.001)，与屈服应变呈弱线性正相关（r(2) = 0.58 n = 53, p = 0.07）。预测错误。当估算来自新供体的标本的模量或强度时产生。为这些性能平均值的30-36%，直接QCT密度-力学性能回归比使用物理测量的湿表观密度作为中间变量来预测QCT密度的力学性能提供了更精确的力学性能预测。使用这些QCT密度-力学特性回归可以提高全骨和骨植入物分析中基于QCT的人类脊柱生物力学模型的保真度。(C) 2002骨科研究学会。Elsevier Science Ltd.出版。版权所有。
The objective of this study was to report our quantitative computed tomography (QCT) density-mechanical property regressions for trabecular bone for use in biomechanical modelling of the human spine. Cylindrical specimens of human vertebral trabecular bone (from T10 to L4) were cored from 32 cadavers (mean +/-SD age = 70.1 +/- 16.8: 13 females, 19 males) and scanned using QCT. Mechanical tests were conducted using a protocol that minimized end-artifacts over the apparent density range tested (0.09-0.38 g/cm(3)). To account for the presence of multiple specimens per donor in this data set, donor was treated as a random effect in the regression model. Mean modulus (319 +/- 189 MPa) was higher and mean yield strain (0.78 +/- 0.06%) was lower than typical values reported previously due to minimization of the end-artifact errors. QCT density showed a strong positive correlation with Modulus (n = 76) and yield stress (r(2) = 0.90 0.95. n = 53, p < 0.001), There as a weak positive linear correlation with yield strain (r(2) = 0.58 n = 53, p = 0.07). Prediction errors. incurred when estimating modulus or strength for specimens from a new donor. were 30-36% of the mean values of these properties, Direct QCT density-mechanical property regressions gave more precise predictions of mechanical properties than if physically measured wet apparent density was used as an intermediate variable to predict mechanical properties from QCT density. Use of these QCT density-mechanical property regressions should improve the fidelity, of QCT-based biomechanical models of the human spine for whole bone and bone-implant analyses. (C) 2002 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.