Prevalence of Actinic Keratosis and Its Risk Factors in the General Population: The Rotterdam Study
Prevalence of Actinic Keratosis and Its Risk Factors in the General Population: The Rotterdam Study
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DOI：
10.1038/jid.2013.134
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发表时间：
2013-08-01
影响因子：
6.5
通讯作者：
Nijsten, Tamar
中科院分区：
文献类型：
--
作者：
Flohil, Sophie C.;van der Leese, Robert J. T.;Nijsten, Tamar
Limited data are available on the prevalence and risk factors of actinic keratoses (AKs). Within the Rotterdam Study, full-body skin examinations were performed among participants aged 45 years or older to estimate the age- and sex-standardized prevalence of AK and its associated risk factors. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for associations between risk factors and the presence of 1-3, 4-9, and >= 10 AKs. Of the 2,061 inspected cohort members (mean age 72 years), 21% had 1-3, 9% had 4-9, and 8% had >= 10 AKs. AK prevalence was 49% (95% CI: 46-52%) for men and 28% (26-31%) for women. Male gender, older age, light pigmentation status, severe baldness, skin wrinkling, and high tendency for sunburn were significantly associated with extensive actinic damage (>= 10 AKs) in the multivariate analyses. Especially bald males were at an increased risk of severe actinic skin damage (adjusted OR = 7.0 (3.8-13.1)). The prevalence of AK is very high, especially among elderly bald males. The prevention and management of AK is a true challenge for patients, physicians, and health-care policymakers.
