Interaction Between Family History of Alcoholism and Locus of Control in the Opioid Regulation of Impulsive Responding Under the Influence of Alcohol
Interaction Between Family History of Alcoholism and Locus of Control in the Opioid Regulation of Impulsive Responding Under the Influence of Alcohol
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DOI：
10.1111/j.1530-0277.2011.01535.x
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发表时间：
2011-11-01
影响因子：
3.2
通讯作者：
Boettiger, Charlotte A.
中科院分区：
文献类型：
--
作者：
Altamirano, Lee J.;Fields, Howard L.;Boettiger, Charlotte A.
背景：纳洛酮（NTX）是一种阿片受体拮抗剂，适用于治疗酒精中毒，这是不是普遍有效。因此，确定NTX行为效应的个体预测因子对于优化其治疗用途至关重要。此外，考虑到酒精中毒治疗期间复发率高，了解NTX与适度酒精摄入相结合时的行为影响很重要。我们之前对戒酒者和对照组的研究表明，更内在的控制点得分预测了NTX上冲动选择的增加（Mitchell等人，2007，Neuropsychopharmacology 32：439-449）。在这里，我们测试这种预测关系是否仍然在适度alcohol intake.Methods的上下文中：在这项研究中，我们测试了急性NTX（50毫克）的影响，冲动的选择，运动抑制，注意力偏差摄入适度乙醇（类似于0.3克/公斤，n = 30）。受试者包括那些从一个类似的1,200加州大学伯克利分校的本科生的基础上的Barratt冲动量表（BIS）的分数招募。结果：冲动的选择与安慰剂会议呼吸酒精浓度呈正相关。在有酗酒家族史的受试者中，控制点再次成为NTX对决策影响的唯一预测因素。我们还发现了一个弱的相互作用BIS分数和NTX的影响冲动choice.Conclusions：我们的研究结果加强了控制点和NTX的影响，在那些有酗酒家族史的决策之间的预测关系，这表明可能的生物学基础，这种关系。
Background: Naltrexone (NTX) is an opioid antagonist indicated for the treatment of alcoholism, which is not universally effective. Thus, identifying individual predictors of NTX's behavioral effects is critical to optimizing its therapeutic use. Moreover, given the high rate of relapse during treatment for alcoholism, understanding NTX's behavioral effects when combined with moderate ethanol intake is important. Our previous study of abstinent alcoholics and control subjects showed that a more internal Locus of Control score predicted increased impulsive choice on NTX (Mitchell et al., 2007, Neuropsychopharmacology 32:439-449). Here, we tested whether this predictive relationship remains in the context of moderate alcohol intake.Methods: In this study, we tested the effect of acute NTX (50 mg) on impulsive choice, motor inhibition, and attentional bias after ingestion of moderate ethanol (similar to 0.3 g/kg, n = 30 subjects). Subjects included those recruited from a pool of similar to 1,200 UC Berkeley undergraduates on the basis of scores on the Barratt Impulsiveness Scale (BIS).Results: Impulsive choice was positively correlated with breath alcohol concentration in placebo sessions. Locus of Control was again the sole predictor of NTX's effect on decision making among subjects with a family history of alcoholism. We also found a weak interaction between BIS scores and NTX's effect on impulsive choice.Conclusions: Our results reinforce the predictive relationship between Locus of Control and NTX's effect on decision making in those with a family history of alcoholism, suggesting a possible biological basis to this relationship.