Immune activation and arterial stiffness in lean adults with HIV on antiretroviral therapy.
Immune activation and arterial stiffness in lean adults with HIV on antiretroviral therapy.
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DOI：
10.4102/sajhivmed.v22i1.1190
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发表时间：
2021
影响因子：
1.7
通讯作者：
Koethe JR
中科院分区：
文献类型：
--
作者：
Kaluba L;Goma F;Guure C;Munsaka S;Mutale W;Heimburger DC;Chikopela T;Koethe JR
更大的T细胞活化与艾滋病毒感染者（PLWH）的血管顺应性降低有关，特别是在超重和肥胖者中。有一个关于免疫激活和动脉硬化之间的艾滋病毒感染者在撒哈拉以南非洲（SSA）的数据匮乏。确定SSA中瘦型PLWH的免疫激活与动脉僵硬度之间的关系。入组了48名接受抗逆转录病毒治疗（ART）>5年的人类免疫缺陷病毒阳性（HIV+）成人和26名HIV阴性成人，所有人的BMI < 25 kg/m2，无CVD病史。根据HIV状态评估血管顺应性与循环CD 4+和CD 8+幼稚、记忆、活化和衰老T细胞以及血清8-异前列腺素的关系。在PLWH的CD 4+和CD 8 + T细胞中观察到增加的免疫活化，分别为16.7%对8.9%和22.0%对12.4%; p < 0.001（两者）。此外，在调整BMI和年龄后，较高比例的衰老CD 4 + T细胞与较低的颈动脉-股动脉脉搏波速度（cfPWV; p = 0.01）相关，而较高比例的活化CD 8 + T细胞与较低的颈动脉-桡动脉脉搏波速度（crPWV; p = 0.04）相关。然而，与HIV对照组相比，PLWH也具有更高的中位颈动脉-股动脉增强指数（cfAiX）（21.1% vs. 6.0%; p < 0.05）。与HIV阴性者相比，我们的瘦PLWH人群具有增加的免疫激活和更高的cfAiX，动脉硬度的标志物。在PLHW长期治疗中，通过crPWV测量的免疫激活和动脉僵硬度之间的负相关性需要进一步阐明。
Greater T-cell activation was associated with reduced vascular compliance amongst persons living with HIV (PLWH) especially among overweight and obese individuals. There is a paucity of data regarding immune activation and arterial stiffness amongst PLWH in sub-Saharan Africa (SSA). To determine the association between immune activation and arterial stiffness in lean PLWH in SSA. Forty-eight human immunodeficiency virus positive (HIV+) adults on antiretroviral therapy (ART) >5 years and 26 HIV-negative adults, all with BMI < 25 kg/m2 and no history of CVD, were enrolled. The relationship of vascular compliance with circulating CD4+ and CD8+ naïve, memory, activated and senescent T cells, and serum 8-isoprostane was assessed by HIV status. Increased immune activation was observed in the CD4+ and CD8+ T cells of PLWH, 16.7% vs. 8.9% and 22.0% vs. 12.4% respectively; p < 0.001 (both). Furthermore, a higher proportion of senescent CD4+ T cells were associated with a lower carotid-femoral pulse wave velocity (cfPWV; p = 0.01), whilst a higher proportion of activated CD8+ T cells were associated with a lower carotid-radial pulse wave velocity (crPWV; p = 0.04), after adjustment for BMI and age. However, PLWH also had a higher median carotid-femoral augmentation index (cfAiX) (21.1% vs. 6.0%; p < 0.05) in comparison to their HIV controls. Our population of lean PLWH had increased immune activation and higher cfAiX, a marker of arterial stiffness, compared to HIV-negative persons. The negative association between immune activation and arterial stiffness as measured by crPWV in PLHW on long-term treatment needs further elucidation.
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DOI：
10.1097/qad.0000000000001093
发表时间：
2016-06-01
期刊：
AIDS (London, England)
影响因子：
--
作者：
Gianesin K;Noguera-Julian A;Zanchetta M;Del Bianco P;Petrara MR;Freguja R;Rampon O;Fortuny C;Camós M;Mozzo E;Giaquinto C;De Rossi A
通讯作者：
De Rossi A
影响因子：
37.8
作者：
Mitchell GF;Hwang SJ;Vasan RS;Larson MG;Pencina MJ;Hamburg NM;Vita JA;Levy D;Benjamin EJ
通讯作者：
Benjamin EJ
DOI：
10.1097/qai.0000000000000311
发表时间：
2014-11-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Karim R;Mack WJ;Kono N;Tien PC;Anastos K;Lazar J;Young M;Desai S;Golub ET;Kaplan RC;Hodis HN;Kovacs A
通讯作者：
Kovacs A
影响因子：
11.5
作者：
Hsu DC;Sereti I
通讯作者：
Sereti I
影响因子：
20.3
作者：
Deeks, SG;Kitchen, CMR;Hecht, FM
通讯作者：
Hecht, FM