A water-soluble and retrievable ruthenium-based probe for colorimetric recognition of Hg(II) and Cys.
A water-soluble and retrievable ruthenium-based probe for colorimetric recognition of Hg(II) and Cys.
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DOI：
10.1016/j.saa.2016.04.011
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发表时间：
2016-08
期刊：
影响因子：
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通讯作者：
Yali Cui;Yuanqiang Hao;Yintang Zhang;Baoxia Liu;Xu Zhu;Peng Qu;Deliang Li;Maotian Xu
中科院分区：
文献类型：
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作者：
Yali Cui;Yuanqiang Hao;Yintang Zhang;Baoxia Liu;Xu Zhu;Peng Qu;Deliang Li;Maotian Xu
本文报道了一种新的钌配合物[（双（4，4 ′-二甲基膦酸-2，2 ′-联吡啶）二硫氰基钌（II）]]作为汞（II）和半胱氨酸（Cys）的比色探针。在100%水溶液中，Hg（II）和Cys交替加入时，化合物1产生相互转化的颜色变化。NCS基团与Hg（II）之间的特异性配位可导致1-Hg 2+络合物的形成，从而引起探针1的光谱变化。该1-Hg ~（2+）络合物可作为半胱氨酸的有效比色传感器。由于巯基对Hg ~（2+）有较强的结合亲和力，Cys可以从1-Hg ~（2+）络合物中萃取Hg ~（2+），从而释放出1，使探针的吸收曲线恢复。通过引入亲水性膦酸基团，该探针具有良好的水溶性。Hg 2+和Cys的检测限（LOD）分别计算为15 nM和200 nM。
A new ruthenium-based complex1[(bis(4,4′-dimethylphosphonic-2,2′-bipyridine) dithiocyanato ruthenium (II))] was developed as a colorimetric probe for the detection of Hg(II) and Cys (Cysteine). The obtained compound1can give interconversional color changes upon the alternating addition of Hg(II) and Cys in 100% aqueous solution. The specific coordination between NCS groups with Hg(II) can lead to the formation of1-Hg2 +complex, which can induce a remarkable spectral changes of probe1. Afterwards the formed1-Hg2 +complex can act as effective colorimetric sensor for Cys. Owing to the stronger binding affinity of sulfhydryl group to Hg2 +, Cys can extract Hg2 +from1-Hg2 +complex resulting in the release of1and the revival of absorption profile of the probe1. By introducing the hydrophilic phosphonic acid groups, the proposed probe exhibited excellent water solubility. The limits of detection (LODs) of the assay for Hg2 +and Cys are calculated to be 15 nM and 200 nM, respectively.