An open investigation of the reproducibility of cancer biology research.
An open investigation of the reproducibility of cancer biology research.
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DOI：
10.7554/elife.04333
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发表时间：
2014-12-10
期刊：
影响因子：
7.7
通讯作者：
Nosek BA
中科院分区：
文献类型：
--
作者：
Errington TM;Iorns E;Gunn W;Tan FE;Lomax J;Nosek BA
人们普遍认为，建立在先前发表的研究结果基础上的研究已经复制了原始工作。然而，研究人员很少执行或发表现有结果的直接复制。生殖生物学项目：癌症生物学是临床前癌症生物学研究中可重复性的开放式调查。我们已经确定了2010-2012年期间发表的50篇高影响力的癌症生物学文章，并计划复制每篇文章的实验结果子集。在数据收集之前，将对详细说明每个实验子集的拟议实验设计和方案的注册报告进行同行评审并发表。这些实验的结果将发表在《复制研究》上。由此产生的开放方法和数据集将提供有关高影响结果的可再现性的证据，并有机会确定可再现性的预测因素。DOI：http://dx.doi.org/10.7554/eLife.04333.001网站
It is widely believed that research that builds upon previously published findings has reproduced the original work. However, it is rare for researchers to perform or publish direct replications of existing results. The Reproducibility Project: Cancer Biology is an open investigation of reproducibility in preclinical cancer biology research. We have identified 50 high impact cancer biology articles published in the period 2010-2012, and plan to replicate a subset of experimental results from each article. A Registered Report detailing the proposed experimental designs and protocols for each subset of experiments will be peer reviewed and published prior to data collection. The results of these experiments will then be published in a Replication Study. The resulting open methodology and dataset will provide evidence about the reproducibility of high-impact results, and an opportunity to identify predictors of reproducibility. DOI: http://dx.doi.org/10.7554/eLife.04333.001