15 N MRI of SLIC-SABRE Hyperpolarized 15 N-Labelled Pyridine and Nicotinamide.
15 N MRI of SLIC-SABRE Hyperpolarized 15 N-Labelled Pyridine and Nicotinamide.
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SLIC-SABRE 超极化 15 N 标记吡啶和烟酰胺的 15 N MRI。
DOI：
10.1002/chem.201900430
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Koptyug,IgorV
中科院分区：
文献类型：
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作者：
Svyatova,Alexandra;Skovpin,IvanV;Chukanov,NikitaV;Kovtunov,KirillV;Chekmenev,EduardY;Pravdivtsev,AndreyN;Hövener,Jan-Bernd;Koptyug,IgorV
磁共振成像（MRI）是一种功能强大的非侵入性诊断方法，广泛用于生物医学研究。MRI的一个显著限制是其相对较低的信噪比，这可以通过超极化核自旋来增加。一种有前途的方法是通过可逆交换的信号放大（SABRE），其采用仲氢作为超极化的来源。最近的研究表明，这种超极化技术可以提高MRI的灵敏度。生物分子中的超极化15N核可以潜在地保持它们的自旋排列数十分钟，为超极化化合物的利用提供了延长的时间窗口。在这项工作中，我们首次证明了基于射频的SABRE超极化技术可用于获得生物分子1 - 15N-烟酰胺的15N MRI。使用并比较了两种图像采集策略：单点成像（SPI）和快速低角度拍摄（FLASH）。这些方法证明了高场SABRE用于生物医学应用的机会。
Magnetic Resonance Imaging (MRI) is a powerful non‐invasive diagnostic method extensively used in biomedical studies. A significant limitation of MRI is its relatively low signal‐to‐noise ratio, which can be increased by hyperpolarizing nuclear spins. One promising method is Signal Amplification By Reversible Exchange (SABRE), which employs parahydrogen as a source of hyperpolarization. Recent studies demonstrated the feasibility to improve MRI sensitivity with this hyperpolarization technique. Hyperpolarized15N nuclei in biomolecules can potentially retain their spin alignment for tens of minutes, providing an extended time window for the utilization of the hyperpolarized compounds. In this work, we demonstrate for the first time that radio‐frequency‐based SABRE hyperpolarization techniques can be used to obtain15N MRI of biomolecule 1‐15N‐nicotinamide. Two image acquisition strategies were utilized and compared: Single Point Imaging (SPI) and Fast Low Angle SHot (FLASH). These methods demonstrated opportunities of high‐field SABRE for biomedical applications.