Rapid, non-invasive measurement of gastric emptying rate using transcutaneous fluorescence spectroscopy.
Rapid, non-invasive measurement of gastric emptying rate using transcutaneous fluorescence spectroscopy.
复制标题
使用经皮荧光光谱法快速、无创地测量胃排空率。
DOI：
10.1364/boe.424252
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发表时间：
2021
影响因子：
3.4
通讯作者：
A. J. Thompson
中科院分区：
文献类型：
--
作者：
Aaron M. Lett;Apiradee Lim;C. Skinner;James B Maurice;N. Vergis;A. Darzi;R. Goldin;M. Thursz;A. J. Thompson
胃排空率（GER）表示进食后胃排空的速度，与广泛的临床状况有关。GER也代表了小肠吸收的速率限制步骤，因此被广泛评估用于研究目的。尽管胃排空在临床和生理上具有重要意义，但用于测量GER的方法存在一系列局限性（包括侵入性、缓慢或不适合某些患者群体）。在这里，我们提出了一种基于经皮（穿过皮肤）荧光光谱的新技术，该技术快速，无创，不需要收集样品或实验室分析。因此，这种方法有可能允许立即报告临床结果。使用这种新方法，参与者接受口服剂量的荧光造影剂，可穿戴探针检测该剂从肠道进入血液的吸收情况。然后对结果数据进行分析，计算GER。我们将我们的光谱技术与20名参与者的临床研究中的扑热息痛吸收试验（一种临床批准的GER试验）进行了比较。结果表明两种方法之间有良好的一致性，因此，经皮荧光光谱在临床评估GER方面具有明确的潜力。
Gastric emptying rate (GER) signifies the rate at which the stomach empties following ingestion of a meal and is relevant to a wide range of clinical conditions. GER also represents a rate limiting step in small intestinal absorption and so is widely assessed for research purposes. Despite the clinical and physiological importance of gastric emptying, methods used to measure GER possess a series of limitations (including being invasive, slow or unsuitable for certain patient populations). Here, we present a new technique based on transcutaneous (through-the-skin) fluorescence spectroscopy that is fast, non-invasive, and does not require the collection of samples or laboratory-based analysis. Thus, this approach has the potential to allow immediate reporting of clinical results. Using this new method, participants receive an oral dose of a fluorescent contrast agent and a wearable probe detects the uptake of the agent from the gut into the blood stream. Analysis of the resulting data then permits the calculation of GER. We compared our spectroscopic technique to the paracetamol absorption test (a clinically approved GER test) in a clinical study of 20 participants. Results demonstrated good agreement between the two approaches and, hence, the clear potential of transcutaneous fluorescence spectroscopy for clinical assessment of GER.