An Introduction to Engineering and Modeling the Lung.
An Introduction to Engineering and Modeling the Lung.
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肺工程和建模简介。
DOI：
10.1007/978-3-031-26625-6_1
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发表时间：
2023
影响因子：
--
通讯作者：
Magin,ChelseaM
中科院分区：
文献类型：
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作者：
Tanneberger,AliciaE;Weiss,DanielJ;Magin,ChelseaM
在过去的十年中，由于许多进步，包括单细胞RNA(ScRNA)测序、诱导多能干细胞(IPSC)重新编程以及3D细胞和组织培养的出现，肺生物学领域取得了长足的进步。尽管进行了严格的研究和不懈的努力，但慢性肺部疾病仍然是全球第三大死亡原因，移植是治疗终末期疾病的唯一选择。本章将介绍了解肺生物学在健康和疾病中的更广泛影响，提供肺生理学和病理生理学的概述，并总结描述肺内稳态和疾病的工程翻译模型的每一章的关键要点。本书分为广泛的主题领域，包括与(1)发育中的肺，(2)大气道，(3)间充质和实质，(4)肺血管，和(5)肺和医疗器械之间的接口有关的基本生物学，工程方法和临床观点的章节。每一节都强调了一个基本前提，即当与细胞生物学家和肺部医生合作应用工程策略时，将解决肺部卫生保健中的关键挑战。
Over the last decade, the field of lung biology has evolved considerably due to many advancements, including the advent of single-cell RNA (scRNA) sequencing, induced pluripotent stem cell (iPSC) reprogramming, and 3D cell and tissue culture. Despite rigorous research and tireless efforts, chronic pulmonary diseases remain the third leading cause of death globally, with transplantation being the only option for treating end-stage disease. This chapter will introduce the broader impacts of understanding lung biology in health and disease, provide an overview of lung physiology and pathophysiology, and summarize the key takeaways from each chapter describing engineering translational models of lung homeostasis and disease. This book is divided into broad topic areas containing chapters covering basic biology, engineering approaches, and clinical perspectives related to (1) the developing lung, (2) the large airways, (3) the mesenchyme and parenchyma, (4) the pulmonary vasculature, and (5) the interface between lungs and medical devices. Each section highlights the underlying premise that engineering strategies, when applied in collaboration with cell biologists and pulmonary physicians, will address critical challenges in pulmonary health care.