Brain-computer interfaces and communication in paralysis: extinction of goal directed thinking in completely paralysed patients?
Brain-computer interfaces and communication in paralysis: extinction of goal directed thinking in completely paralysed patients?
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DOI：
10.1016/j.clinph.2008.06.019
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发表时间：
2008-11
期刊：
影响因子：
--
通讯作者：
Birbaumer N
中科院分区：
文献类型：
--
作者：
Kübler A;Birbaumer N
目的：探讨肢体损伤与脑机接口(BCI)功能的关系。我们提出了一项荟萃分析，对29名肌萎缩侧索硬化症患者和6名其他严重神经疾病患者进行了BCI训练，这些患者处于不同的身体损害阶段。在大多数情况下，脑机接口控制的输入信号是对皮层慢电位的自主调节。最近，记录了感觉运动节律和P300事件相关脑电位。身体损伤和脑机接口表现之间存在很强的相关性，表明随着损伤的增加，表现会变差。7名患者处于完全锁定状态(CLI)，无法进行交流。在将这些患者从分析中剔除后，身体损伤和脑机接口表现之间的关系消失了。当添加来自其他BCI研究组的患者的BCI数据时，证实了身体损伤与BCI表现之间缺乏联系。所有患有脑梗塞的CLIS患者的基本交流(是/否)均未恢复。被锁定的患者是否可以将习得的大脑控制转移到CLI，这仍然是一个悬而未决的经验性问题。除CLI外，瘫痪的所有阶段都有可能对大脑进行自愿的沟通调节。
To investigate the relationship between physical impairment and brain-computer interface (BCI) performance. We present a meta-analysis of 29 patients with amyotrophic lateral sclerosis and 6 with other severe neurological diseases in different stages of physical impairment who were trained with a BCI. In most cases voluntary regulation of slow cortical potentials has been used as input signal for BCI control. More recently sensorimotor rhythms and the P300 event-related brain potential were recorded. A strong correlation has been found between physical impairment and BCI performance, indicating that performance worsens as impairment increases. Seven patients were in the complete locked-in state (CLIS) with no communication possible. After removal of these patients from the analysis, the relationship between physical impairment and BCI performance disappeared. The lack of a relation between physical impairment and BCI performance was confirmed when adding BCI data of patients from other BCI research groups. Basic communication (yes/no) was not restored in any of the CLIS patients with a BCI. Whether locked-in patients can transfer learned brain control to the CLIS remains an open empirical question. Voluntary brain regulation for communication is possible in all stages of paralysis except the CLIS.
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影响因子：
5.1
作者：
Kotchoubey, B;Lang, S;Birbaumer, N
通讯作者：
Birbaumer, N
影响因子：
9.9
作者：
Kübler, A;Nijboer, F;Wolpaw, JR
通讯作者：
Wolpaw, JR
DOI：
10.1016/s0003-9993(98)90165-4
发表时间：
1998-09-01
影响因子：
4.3
作者：
Miner, LA;McFarland, DJ;Wolpaw, JR
通讯作者：
Wolpaw, JR
影响因子：
1.3
作者：
Kübler, A;Neumann, N;Birbaumer, N
通讯作者：
Birbaumer, N
影响因子：
56.9
作者：
MILLER, NE
通讯作者：
MILLER, NE