EXOGENOUS CONTROL OF FOLLICULAR WAVE EMERGENCE IN CATTLE
EXOGENOUS CONTROL OF FOLLICULAR WAVE EMERGENCE IN CATTLE
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DOI：
10.1016/0093-691x(94)00010-r
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发表时间：
1995-01-01
期刊：
影响因子：
2.8
通讯作者：
MAPLETOFT, RJ
中科院分区：
文献类型：
--
作者：
BO, GA;ADAMS, GP;MAPLETOFT, RJ
牛卵巢对超刺激治疗的反应以及从PGF（2 α）治疗至发情的时间间隔的变异性主要归因于治疗时卵泡波发育的状态。迄今为止，大多数设计用于控制卵泡波发育的治疗都是基于去除优势卵泡的抑制作用，无论是物理（通过电烙术或超声引导卵泡消融术）还是经尿道（通过GnRH或雌二醇和孕激素治疗），从而在治疗后的特定时间诱导新的卵泡波出现。用雌二醇-17 β（E-17 β）处理孕激素植入牛导致优势卵泡受到抑制，并在4.3 +/-0.1天后出现新的卵泡波。在孕激素植入牛中，E-17 β治疗后4天开始的超刺激治疗导致超排卵反应，与在第二卵泡波开始超刺激治疗的牛相当。在另一项研究中，诱导卵泡波的出现，无论发情周期的阶段，导致类似的超排卵反应和更高的受精率在小母牛比超刺激治疗时开始发情后8至12天（传统方法）。最后，用E-17 β加孕酮和PGF（2 α）进行同期发情处理，可导致同期发情和排卵。总的来说，似乎E-17 β和孕激素联合治疗可用于有效控制和同步卵泡波发育，并可能在卵巢周期性和超排卵的人工控制中具有重要意义。
Variability in ovarian response to superstimulatory treatments and in the interval from PGF(2 alpha) treatment to estrus in cattle is largely attributable to the status of follicular wave development at the time of treatment. To date, most treatments designed to control follicular wave development have been based on removal of the suppressive effect of the dominant follicle, either physically (by electrocauterization or ultrasound-guided follicle ablation) or hormonally (by GnRH or estradiol and progestogen treatment), and thereby induce the emergence of a new follicular wave at a specific time after treatment. Treatment of progestogen-implanted cattle with estradiol-17 beta (E-17 beta) resulted in suppression of the dominant follicle and emergence of a new follicular wave 4.3 +/- 0.1 d later. Superstimulatory treatments initiated 4 d after E-17 beta treatment in progestogen-implanted cattle resulted in a superovulatory response comparable to that of cattle in which superstimulatory treatments were initiated on the second follicular wave. In another study, induced follicular wave emergence, regardless of the stage of the estrous cycle, resulted in similar superovulatory response and higher fertilization rates in heifers than when superstimulatory treatments were initiated 8 to 12 d after estrus (traditional approach). Finally, estrus synchronization treatments with E-17 beta plus progesterone and PGF(2 alpha) have resulted in synchronous estrus and ovulation. Overall, it appears that treatment with E-17 beta and progestogen in combination may be used to effectively control and synchronize follicular wave development and may have important implications in artificial control of ovarian cyclicity and superovulation.