MEMBRANE WATER PARTITION OF OLIGO(ETHYLENE OXIDE) DODECYL ETHERS AND ITS RELEVANCE FOR SOLUBILIZATION
MEMBRANE WATER PARTITION OF OLIGO(ETHYLENE OXIDE) DODECYL ETHERS AND ITS RELEVANCE FOR SOLUBILIZATION
复制标题
DOI：
10.1016/0005-2736(94)00222-3
复制
发表时间：
1994-12-30
影响因子：
3.4
通讯作者：
KLOSE, G
中科院分区：
文献类型：
--
作者：
HEERKLOTZ, H;BINDER, H;KLOSE, G
本文研究了棕榈酰油酰磷脂酰胆碱和低聚环氧乙烷十二烷基醚C（12）EO（n）（n = 2-8）的混合水分散体。聚集体组合物已被确定为使用Laurdan荧光光谱的水性洗涤剂浓度的函数。根据常规溶液模型分析了洗涤剂在膜和水相之间的分配。使用水相、双层相和胶束假相的热力学共存条件，根据膜中的限制洗涤剂分数、胶束中的最小洗涤剂分数和临界水性洗涤剂浓度来分析增溶作用。提出了增溶的热力学判据。去污剂从水向双层膜转移的标准化学势差符合经验关系Δ μ度（n = 2-8）= -37.6 +0.9nkJ/mol。因此，一个类似的构象和本地化的oxidophosphorus单位内的膜建议。
Mixed aqueous dispersions containing palmitoyloleoylphosphatidylcholine and oligo(ethylene oxide) dodecyl ethers C(12)EO(n) with n = 2-8 have been investigated. The aggregates composition has been determined as a function of the aqueous detergent concentration using Laurdan fluorescence spectroscopy. The partition of the detergent between the membranes and the aqueous phase has been analyzed on the basis of the regular solution model. Solubilization has been analyzed in terms of the limiting detergent fraction in the membrane, the minimal detergent fraction in micelles and the critical aqueous detergent concentration using thermodynamical coexistence conditions for the aqueous, bilayer and micellar pseudo-phases. A thermodynamic criterion for solubilization is presented. The standard chemical potential differences of the transfer of the detergents from water to the bilayer have been found to follow the empirical relation Delta mu degrees(n = 2-8)= -37.6 + 0.9n kJ/mol. Thus, a similar conformation and localization of the oxyethylene units within the membrane are suggested.