Screening of a supramolecular catalyst library in the search for selective catalysts for the asymmetric hydrogenation of a difficult enamide substrate
Screening of a supramolecular catalyst library in the search for selective catalysts for the asymmetric hydrogenation of a difficult enamide substrate
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DOI：
10.1002/anie.200503663
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发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
Reek, JNH
中科院分区：
文献类型：
--
作者：
Jiang, XB;Lefort, L;Reek, JNH
试剂购自Aldrich、Acros、Fluka、Merck、斯特雷姆，并且除非另有说明，否则不经任何进一步纯化直接使用。大多数溶剂为分析级，必要时根据标准程序进行纯化。1H NMR（300 MHz）、13 C NMR（75.4 MHz）和31 P NMR（121.4 MHz）光谱在Varian Mercury 300光谱仪上在CDCl 3中记录。相对于CHCl 3的残余氘代溶剂信号（1H：7.25ppm，13 C：77.0ppm）以d单位（ppm）记录化学位移;分裂模式指定如下：s（单峰）、d（双峰）、t（三重峰）、q（四重峰）、m（多重峰）。耦合常数（J）以赫兹（Hz）记录。记录的光谱与最终化合物的拟定结构一致。使用FAB电离在AEI-MS-902质谱仪上测量质谱。根据文献方法制备羟基卟啉和L1-L2、L4-L7、L '1、L' 3-L '5、L' 7。1 L3购自Aldrich。根据公开的方法制备L12。2
Reagents were purchased from Aldrich, Acros, Fluka, Merck, Strem and used as received without any further purification unless stated otherwise. Most solvents were analytical grade and purified according to standard procedures, if necessary. 1 H NMR (300 MHz), 13 C NMR (75.4 MHz) and 31 P NMR (121.4 MHz) spectra were recorded on a Varian Mercury 300 spectrometer in CDCl3. Chemical shifts were recorded in d units (ppm) relative to the residue deuterated solvent signals of CHCl3 ( 1 H: 7.25 ppm, 13 C: 77.0 ppm); the splitting patterns are designated as follows: s (singlet), d (doublet), t (triplet), q (quartet), m (multiplet). Coupling constants (J) are recorded in Hertz (Hz). The spectra recorded were consistent with the proposed structures of final compounds. Mass spectra were measured on an AEI-MS-902 mass spectrometer using FAB ionization. The hydroxyl porphyrins and L1-L2, L4-L7, L’1, L’3-L’5, L’7 were prepared according to literature procedure. 1 L3 was purchased from Aldrich. L12 was prepared according to published procedure. 2