The Impact of Family History of Allergy on Risk of Food Allergy: A Population-Based Study of Infants
The Impact of Family History of Allergy on Risk of Food Allergy: A Population-Based Study of Infants
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DOI：
10.3390/ijerph10115364
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发表时间：
2013-11-01
影响因子：
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通讯作者：
Dharmage, Shyamali C.
中科院分区：
文献类型：
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作者：
Koplin, Jennifer J.;Allen, Katrina J.;Dharmage, Shyamali C.
ige介导的食物过敏的明显迅速增加及其影响现已得到广泛认识，但对家族史（遗传风险的间接衡量标准）与食物过敏风险之间的关系知之甚少。在一项以人口为基础的研究中，5276名一岁婴儿（HealthNuts），测量了口腔食物挑战证实的食物过敏的患病率。使用多元逻辑回归检验婴儿过敏性疾病家族史与食物过敏之间的关系。534名婴儿被诊断为食物过敏。与没有过敏性疾病家族史的儿童相比，符合当前过敏性疾病“高风险”定义的儿童（有一个直系亲属有任何过敏性疾病史）的食物过敏发生率仅适度增加（OR 1.4, 95% CI 1.1-1.7），而有两个或两个以上过敏家庭成员的儿童更能预测食物过敏（OR 1.8, 95% CI 1.5-2.3）。家族史与儿童鸡蛋和花生过敏之间的关联也存在差异。将“高风险”重新定义为两个或两个以上的过敏家庭成员，可能对临床和研究中食物过敏风险显著增加的人群的识别更有用。
The apparent rapid increase in IgE-mediated food allergy and its implications are now widely recognized, but little is known about the relationship between family history (an indirect measure of genetic risk) and the risk of food allergy. In a population-based study of 5,276 one year old infants (HealthNuts), the prevalence of oral food challenge-confirmed food allergy was measured. Associations between family history of allergic disease and food allergy in infants were examined using multiple logistic regression. Food allergy was diagnosed in 534 infants. Compared to those with no family history of allergic disease, children meeting the current definition of "high risk" for allergic disease (one immediate family member with a history of any allergic disease) showed only a modest increase (OR 1.4, 95% CI 1.1-1.7) in food allergy, while having two or more allergic family members was more strongly predictive of food allergy in the child (OR 1.8, 95% CI 1.5-2.3). There were also differences in the associations between family history and egg and peanut allergy in the child. Re-defining "high risk" as two or more allergic family members may be more useful for identification of groups with a significantly increased risk of food allergy both clinically and within research studies.