Selective identification of Valpha14i T cells using slide-immobilized, CD1d-antigen complexes.
Selective identification of Valpha14i T cells using slide-immobilized, CD1d-antigen complexes.
复制标题
使用载玻片固定的 CD1d 抗原复合物选择性鉴定 Valpha14i T 细胞。
DOI：
10.1080/15321810600734893
复制
发表时间：
2006
影响因子：
--
通讯作者：
Taparowsky,ElizabethJ
中科院分区：
文献类型：
--
作者：
Zullo,AlfredJ;Brutkiewicz,RandyR;Taparowsky,ElizabethJ
The ability to correlate changes in antigen‐reactive lymphocytes with disease will provide information needed to develop strategies for combating illness. One critical group of lymphocytes are the CD1‐restricted T cells. It is desirable to use CD1 molecules in an array format to query CD1‐restricted lymphocytes in humans. To investigate the feasibility of this technique, we employed mCD1d and α‐galactosylceramide to demonstrate that‐slide immobilized, CD1d‐α‐GalCer complexes capture an NKT cell hybridoma in the presence of a competitor. The success of this scheme represents the first step toward the development of CD1‐antigen arrays that could be used to profile biological samples.
