Capsaicin attenuates suppression of sham feeding induced by intestinal nutrients.
Capsaicin attenuates suppression of sham feeding induced by intestinal nutrients.
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辣椒素减弱肠道营养物引起的假喂养的抑制。
DOI：
10.1152/ajpregu.1988.255.4.r569
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Ritter,RC
中科院分区：
文献类型：
--
作者：
Yox,DP;Ritter,RC
饱腹感似乎在一定程度上是由胃肠道神经传递的信号调节的。辣椒素是一种神经毒素，它选择性地破坏小的无髓鞘初级感觉神经元，包括一些支配腹部内脏的神经元。因此，我们研究了八肽缩胆囊素(CCK-8)或肠内营养输注对辣椒素处理的大鼠假喂养的抑制作用。在辣椒素处理的大鼠中，CCK-8诱导的假喂食抑制显著减弱。在辣椒素处理的大鼠中，肠内注入麦芽糖、油酸或L-苯丙氨酸引起的假喂养抑制也被减弱。相反，辣椒素处理并不能减弱肠道内酪蛋白水解物(混合氨基酸)对假喂食的抑制。肠道内注入辛酸或D-苯丙氨酸溶液并不能显著抑制给药或辣椒素处理的大鼠的假喂食。这些结果表明，某些肠道刺激对摄食的抑制可能是由对辣椒素损伤或破坏敏感的营养或多肽敏感的内脏传入神经元介导的。
Satiety appears to be mediated in part by neurally transmitted signals from the gastrointestinal tract. Capsaicin is a neurotoxin that selectively destroys small unmyelinated primary sensory neurons including some of those innervating the abdominal viscera. Therefore, we examined suppression of sham feeding induced by cholecystokinin octapeptide (CCK-8) or intraintestinal nutrient infusions in capsaicin-treated rats. Suppression of sham feeding induced by CCK-8 was significantly attenuated in rats treated with capsaicin. Suppression of sham feeding induced by intraintestinal infusions of maltose, oleic acid, or L-phenylalanine was also attenuated in capsaicin-treated rats. In contrast, capsaicin treatment did not attenuate the suppression of sham feeding induced by intraintestinal casein hydrolysate (mixed amino acids). Intraintestinal infusions of octanoic acid or D-phenylalanine solutions did not significantly suppress sham feeding in either vehicle- or capsaicin-treated rats. These results indicate that the suppression of feeding by some intestinal stimuli may be mediated by nutrient or peptide-sensitive visceral afferent neurons that are sensitive to damage or destruction by capsaicin.