OXYTOCIN INHIBITS FOOD AND FLUID INTAKE IN RATS
OXYTOCIN INHIBITS FOOD AND FLUID INTAKE IN RATS
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DOI：
10.1016/0031-9384(90)90234-u
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发表时间：
1990-12-01
影响因子：
2.9
通讯作者：
BERTOLINI, A
中科院分区：
文献类型：
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作者：
ARLETTI, R;BENELLI, A;BERTOLINI, A
越来越多的证据间接表明，催产素能神经元在摄食行为的控制中的作用。本研究旨在直接研究催产素对大鼠食物和水摄入的可能影响。催产素，无论是脑室内（ICV） （1-10 μ g/大鼠）还是腹腔内（IP） （375- 3000 μ g/kg）剂量依赖性地抑制自由饲养动物的食物摄入；在禁食21小时的定时喂养动物中，催产素不仅减少了食物摄入量，而且缩短了进食时间，增加了第一餐的潜伏期。另一方面，催产素拮抗剂d(CH-2)5Tyr(Me)-[Orn8]-缩宫素，ICV注射剂量为10 μ g/大鼠，可增加进食量和进食时间，缩短首餐潜伏期；此外，它完全阻止了催产素的作用。研究了自由饮水动物和三种不同口渴模型（缺水、高渗生理盐水、注射血管紧张素II）的饮水情况。在所有情况下，催产素剂量依赖性地抑制水摄入，剂量范围为0.1-10 μ g/大鼠（ICV）或93-750 μ g/kg （IP）。在缺水模型中，d(CH-2)5Tyr(Me)-[Orn8]- vaso催产素对ICV预处理完全阻断了催产素的抗糖尿病作用。总之，这些数据表明，催产素直接抑制大鼠的食物和水的摄入，这种作用是由大脑催产素受体特异性介导的。这可能支持大脑催产素系统在摄食行为的调节中起重要作用的观点。
Increasing evidence indirectly suggests a role for oxytocinergic neurons in the control of ingestive behaviors. The present study was aimed at directly investigating a possible effect of oxytocin on food and water intake in rats. Oxytocin, whether administered intracerebroventricularly (ICV) (1-10-mu-g/rat) or intraperitoneally (IP) (375-3,000-mu-g/kg) dose dependently inhibited food intake in freely feeding animals; in schedule-fed animals fasting for 21 h, oxytocin not only reduced food intake but also reduced the time spent eating and increased the latency to first meal. On the other hand, oxytocin antagonist d(CH-2)5Tyr(Me)-[Orn8]-vasotocin, ICV injected at the dose of 10-mu-g/rat, increased food intake and time spent eating and reduced the latency to first meal; moreover, it completely prevented the effect of oxytocin. Water intake was studied both in freely drinking animals and in three different models of thirst (water deprivation, hypertonic saline administration, angiotensin II injection). In all cases, oxytocin dose dependently inhibited water intake, in a dose range of 0.1-10-mu-g/rat (ICV) or 93-750-mu-g/kg (IP). In the water deprivation model, ICV pretreatment with d(CH-2)5Tyr(Me)-[Orn8]-vasotocin completely prevented the antidipsogenic effect of oxytocin. In conclusion, these data show that oxytocin directly inhibits food and water intake in rats, the effect being specifically mediated by brain oxytocin receptors. This may support the idea that the brain oxytocinergic system plays an important role in the regulation of ingestive behaviors.