Visual Performance with Wave Aberration Correction after Penetrating, Deep Anterior Lamellar, or Endothelial Keratoplasty
Visual Performance with Wave Aberration Correction after Penetrating, Deep Anterior Lamellar, or Endothelial Keratoplasty
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DOI：
10.1167/iovs.12-10003
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发表时间：
2012-07-01
影响因子：
4.4
通讯作者：
Hindman, Holly B.
中科院分区：
文献类型：
--
作者：
Pantanelli, Seth M.;Sabesan, Ramkumar;Hindman, Holly B.
目的.通过量化穿透性角膜移植术（PK）、深前板层角膜移植术（DALK）或后弹力层剥脱式自动内皮角膜移植术（DSAEK）后高阶像差（HOA）矫正获得的最佳矫正视力（VA）和对比敏感度（CS）的改善，研究眼像差对视觉性能的贡献。对14例受试者的16只眼进行了评价，这些受试者在研究入组前接受了超过1年的PK（n = 5）、DALK（n = 6）或DSAEK（n = 5）。测量眼像差，并使用自适应光学系统来校正眼低阶像差（LOA）和HOA。测量每个受试者的VA和CS，并进行LOA或全像差校正。在三个空间频率中的每一个下测量CS：4、8和12个循环/deg. frequencies。所有角膜移植术组的像差均大于正常近视人群，并且在全像差矫正后视力显著增加（P < 0.0013）。PK受试者的VA优于LOA校正后的DSAEK受试者（logMARVA 0.03 +/- 0.05 vs. 0.25 +/- 0.05; P= 0.0870）。HOA校正后，这种趋势持续存在（P=0.1734）。与PK和DALK受试者相比，DSAEK受试者从全像差校正中获得的VA获益较少。尽管高阶均方根值不同，但所有角膜移植术组均显示出相似的全像差矫正CS获益。PK眼的logMAR VA优于LOA矫正的DSAEK眼，而DALK眼的logMAR VA介于两者之间。当应用完全校正时，同样的趋势持续存在。研究结果表明，畸变以外的因素有助于减少VA与DSAEK相比，PK。（Invest Ophthalmol维斯科学。2012;53：4797-4804）DOI：10.1167/iovs.12-10003
PURPOSE. To investigate the contribution ocular aberrations have on visual performance by quantifying improvements in best-corrected visual acuity (VA) and contrast sensitivity (CS) obtained with higher-order aberration (HOA) correction after penetrating (PK), deep anterior lamellar (DALK), or Descemet's stripping automated endothelial keratoplasty (DSAEK).METHODS. Sixteen eyes were evaluated from 14 subjects who underwent PK (n = 5), DALK (n = 6), or DSAEK (n = 5) greater than 1 year prior to study enrollment. Ocular aberrations were measured and an adaptive optics system was used to correct ocular lower-order aberration (LOA) and HOA. VA and CS were measured for each subject with LOA or full-aberration correction. CS was measured at each of three spatial frequencies: 4, 8, and 12 cycles/deg.RESULTS. All keratoplasty groups had more aberration than that of a normal myopic population and experienced significant VA gains with full-aberration correction (P < 0.0013). PK subjects had better VA than that of DSAEK subjects with LOA correction (logMARVA 0.03 +/- 0.05 vs. 0.25 +/- 0.05; P=.0870). After HOA correction this trend persisted (P=0.1734). DSAEK subjects also experienced less VA benefit from full-aberration correction than that of PK and DALK subjects. All keratoplasty groups demonstrated similar CS benefits from full-aberration correction despite differing higher-order root-mean-square magnitudes.CONCLUSIONS. PK eyes had better logMAR VA than that of DSAEK eyes with LOA correction, whereas DALK eyes performed intermediate between the two. When full correction was applied, the same trend persisted. The findings suggest that factors other than aberration contribute to decrements in VA with DSAEK compared with PK. (Invest Ophthalmol Vis Sci. 2012;53:4797-4804) DOI:10.1167/iovs.12-10003