RNA editing and its control in hepatitis delta virus replication.

RNA editing and its control in hepatitis delta virus replication.
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DOI:
10.3390/v2010131
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发表时间:
2010-01
期刊:
Viruses
影响因子:
--
通讯作者:
Casey JL
Casey JL
中科院分区:
其他
文献类型:
--
作者:
Chen R;Linnstaedt SD;Casey JL

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The hepatitis delta virus genome is a small circular RNA, similar to viroids. Although HDV contains a gene, the protein produced (HDAg) is encoded by less than half the genome and possesses no RNA polymerase activity. Because of this limited coding capacity, HDV relies heavily on host functions and on structural features of the viral RNA—very much like viroids. The virus’ use of host RNA editing activity to produce two functionally distinct forms of HDAg is a particularly good example of this reliance. This review covers the mechanisms and control of RNA editing in the HDV replication cycle.
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