Naturally Occurring Polymorphisms of the Mouse Gammaretrovirus Receptors CAT-1 and XPR1 Alter Virus Tropism and Pathogenicity.
Naturally Occurring Polymorphisms of the Mouse Gammaretrovirus Receptors CAT-1 and XPR1 Alter Virus Tropism and Pathogenicity.
复制标题
小鼠伽马逆转录病毒受体 CAT-1 和 XPR1 的天然多态性改变病毒的趋向性和致病性。
DOI：
10.1155/2011/975801
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发表时间：
2011
影响因子：
2.2
通讯作者：
Kozak,ChristineA
中科院分区：
文献类型：
--
作者：
Kozak,ChristineA
已经从实验室小鼠中分离出几种不同宿主范围亚群的γ逆转录病毒。亲嗜性病毒感染小鼠细胞并依赖于宿主CAT-1受体。异嗜性/多嗜性病毒和相关的人源性XMRV可以感染其他哺乳动物物种的细胞，并使用XPR 1受体进入。这些病毒及其受体在受感染小鼠种群中的共同进化为遗传冲突如何推动多样化选择提供了一个很好的例子。病毒包膜糖蛋白中的遗传和表观遗传变异可导致宿主范围和致病性改变，并且受体的病毒结合位点的变化负责减少病毒进入或完全阻断病毒进入的宿主限制。这些战场区域以突变变化为标志，这些突变变化在小鼠中产生了CAT-1受体的2种功能不同的变体和XPR 1受体的5种变体，以及一组不同的感染性病毒和几种被宿主吸收以干扰进入的内源性逆转录病毒。
Gammaretroviruses of several different host range subgroups have been isolated from laboratory mice. The ecotropic viruses infect mouse cells and rely on the host CAT‐1 receptor. The xenotropic/polytropic viruses, and the related human‐derived XMRV, can infect cells of other mammalian species and use the XPR1 receptor for entry. The coevolution of these viruses and their receptors in infected mouse populations provides a good example of how genetic conflicts can drive diversifying selection. Genetic and epigenetic variations in the virus envelope glycoproteins can result in altered host range and pathogenicity, and changes in the virus binding sites of the receptors are responsible for host restrictions that reduce virus entry or block it altogether. These battleground regions are marked by mutational changes that have produced 2 functionally distinct variants of the CAT‐1 receptor and 5 variants of the XPR1 receptor in mice, as well as a diverse set of infectious viruses, and several endogenous retroviruses coopted by the host to interfere with entry.