GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program
GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program
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DOI：
10.1371/journal.pgen.1002829
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发表时间：
2012-07-01
期刊：
影响因子：
4.5
通讯作者：
Andersen, Bogi
中科院分区：
文献类型：
--
作者：
Hopkin, Amelia Soto;Gordon, William;Andersen, Bogi
Polycomb和Trithorax的拮抗作用负责哺乳动物组织中适当的细胞命运决定。在表皮，自我更新的上皮，以前的工作表明，从Polycomb抑制释放只能部分解释分化基因激活。我们现在表明，Trithorax也是表皮分化的关键调节因子，不仅通过激活祖细胞中受Polycomb抑制的基因，而且通过激活不受Polycomb调控的基因。分化相关转录因子GRHL 3/GET 1将广泛表达的Trithorax复合物募集到分化基因的子集。
The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous work has shown that release from Polycomb repression only partially explains differentiation gene activation. We now show that Trithorax is also a key regulator of epidermal differentiation, not only through activation of genes repressed by Polycomb in progenitor cells, but also through activation of genes independent of regulation by Polycomb. The differentiation associated transcription factor GRHL3/GET1 recruits the ubiquitously expressed Trithorax complex to a subset of differentiation genes.