Inhibition of invasion by glycogen synthase kinase-3 beta inhibitors through dysregulation of actin re-organisation via down-regulation of WAVE2.
Inhibition of invasion by glycogen synthase kinase-3 beta inhibitors through dysregulation of actin re-organisation via down-regulation of WAVE2.
复制标题
糖原合酶激酶 3 β 抑制剂通过下调 WAVE2 导致肌动蛋白重组失调，从而抑制侵袭。
DOI：
10.1016/j.bbrc.2015.06.142
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发表时间：
2015
影响因子：
3.1
通讯作者：
C. Ishioka
中科院分区：
文献类型：
--
作者：
Yuki Yoshino;Manami Suzuki;H. Takahashi;C. Ishioka
癌细胞侵袭是肿瘤发病机制中的一个重要现象。糖原合成酶-3β(GSK-3β)对癌细胞的侵袭具有正、负向调节作用。因此，葛兰素史克-3β对入侵的净影响尚不清楚。在这篇报道中，我们发现GSK-3β抑制剂导致肌动蛋白细胞骨架的失调和局部黏附功能的不足，从而导致侵袭性的抑制。此外，肌动蛋白纤维分支的关键分子WAVE2在GSK-3β抑制后下调。总之，我们认为WAVE2-肌动蛋白细胞骨架轴是GSK-3β抑制剂在癌细胞侵袭中的一个重要靶点。
Cancer cell invasion is a critical phenomenon in cancer pathogenesis. Glycogen synthase kinase-3β (GSK-3β) has been reported to regulate cancer cell invasion both negatively and positively. Thus, the net effect of GSK-3β on invasion is unclear. In this report, we showed that GSK-3β inhibitors induced dysregulation of the actin cytoskeleton and functional insufficiency of focal adhesion, which resulted in suppressed invasion. In addition, WAVE2, an essential molecule for actin fibre branching, was down-regulated after GSK-3β inhibition. Collectively, we propose that the WAVE2-actin cytoskeleton axis is an important target of GSK-3β inhibitors in cancer cell invasion.
影响因子：
5.3
作者：
Kobayashi, T;Hino, S;Kikuchi, A
通讯作者：
Kikuchi, A
影响因子：
5.7
作者：
Shakoori, Abbas;Mai, Wei;Minamoto, Toshinari
通讯作者：
Minamoto, Toshinari