Origin and Occurrence of Human Chorionic Gonadotropin β-Subunit Core Fragment
Origin and Occurrence of Human Chorionic Gonadotropin β-Subunit Core Fragment
复制标题
人绒毛膜促性腺激素β亚基核心片段的起源和发生
DOI：
--
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
S. Birken
中科院分区：
文献类型：
--
作者：
L. Cole;S. Birken
人绒毛膜促性腺激素（hCG）β亚基核心片段（β片段）存在于妊娠个体以及滋养层疾病和某些其他癌症患者的尿液中，浓度为hCG的0.8倍（妊娠早期）至7倍（妊娠中期）。核心片段可以由滋养层组织直接分泌到循环中，或者可能来源于肾脏对循环激素的外周降解。我们研究了前一种假设。我们研究了24小时的滋养层组织培养的早期，中期和晚期妊娠。来自该组织的培养基含有hCG、游离β-亚基和β-片段。β片段的量超过hCG的量，如在中期和晚期妊娠尿液中观察到的。将滋养层组织产生的β片段免疫反应物质与尿β片段的标准制备物进行比较。介质中的物质与标准β片段的洗脱模式完全一致。
Human chorionic gonadotropin (hCG) β-subunit core fragment (β-fragment) is present in the urine of pregnant individuals as well as those with trophoblast disease and certain other cancers at concentrations 0.8 (early pregnancy) to 7 (second trimester pregnancy)-fold greater than that of hCG. The core fragment may be directly secreted by trophoblast tissue into the circulation or possibly originates from peripheral degradation of circulating hormone by the kidney. We examined the former hypothesis. We examined 24-h organ cultures of trophoblast tissue from first, second, and third trimester pregnancy. The media from this tissue contained hCG, free β-subunit, and β-fragment. The amount of β-fragment present exceeded that of hCG, as was observed in second and third trimester pregnancy urine. The β-fragment immunoreactive material produced by trophoblast tissue was compared to a standard preparation of urinary β-fragment. The material in medium was identical to the standard β-fragment in its elution pattern f...
hCG 游离 β 亚基是体外受精临床妊娠结果的早期标志。
DOI：
10.1210/jcem-64-6-1328
发表时间：
1987
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Cole,LA;Restrepo-Candelo,H;Lavy,G;Decherney,A
通讯作者：
Decherney,A
人绒毛膜癌细胞合成的绒毛膜促性腺激素的αβ二聚体和未组合的α和β亚基的加工和分泌的动力学比较。
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Peters,BP;Krzesicki,RF;Hartle,RJ;Perini,F;Ruddon,RW
通讯作者：
Ruddon,RW
妊娠血清中人绒毛膜促性腺激素 (hCG) 游离 β 和游离 α 亚基的差异出现。
DOI：
10.1210/jcem-58-6-1200
发表时间：
1984
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Cole,LA;Kroll,TG;Ruddon,RW;Hussa,RO
通讯作者：
Hussa,RO