MultiCoil: A program for predicting two- and three-stranded coiled coils
MultiCoil: A program for predicting two- and three-stranded coiled coils
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DOI：
10.1002/pro.5560060606
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发表时间：
1997-06-01
期刊：
影响因子：
8
通讯作者：
Berger, B
中科院分区：
文献类型：
--
作者：
Wolf, E;Kim, PS;Berger, B
在多线圈程序中实现了一种识别和区分三聚体和维度线圈的新的多维评分方法。该程序将双股螺旋线圈预测程序PairCoil扩展到三股螺旋线圈的识别。这些计算是基于从包含6,319个氨基酸残基的三链螺旋数据库收集的数据，以及从先前构建的两链螺旋数据库收集的数据。除了识别双链数据库程序没有预测的盘绕线圈外，MultiCoil还准确地对已知的二聚体和三聚体盘绕线圈的齐聚状态进行分类。对MultiCoil分数的分析提供了对螺旋螺旋结构特征的洞察，并产生了估计所有蛋白质残基的0.9%形成三股螺旋螺旋和1.5%形成两股螺旋螺旋的估计。多线圈计划可在http://theory.lcs.mit.edu/multicoil.上获得
A new multidimensional scoring approach for identifying and distinguishing trimeric and dimenic coiled coils is implemented in the MultiCoil program. The program extends the two-stranded coiled-coil prediction program PairCoil to the identification of three-stranded coiled coils. The computations are based upon data gathered from a three-stranded coiled-coil database comprising 6,319 amino acid residues, as well as from the previously constructed two-stranded coiled-coil database. In addition to identifying coiled coils not predicted by the two-stranded database programs, MultiCoil accurately classifies the oligomerization states of known dimeric and trimeric coiled coils. Analysis of the MultiCoil scores provides insight into structural features of coiled coils, and yields estimates that 0.9% of all protein residues form three-stranded coiled coils and that 1.5% form two-stranded coiled coils. The MultiCoil program is available at http://theory.lcs.mit.edu/multicoil.