Membrane deformation by protein coats
Membrane deformation by protein coats
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DOI：
10.1016/j.ceb.2006.06.003
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发表时间：
2006-08-01
影响因子：
7.5
通讯作者：
Antonny, Bruno
中科院分区：
文献类型：
--
作者：
Antonny, Bruno
蛋白质外壳使脂质膜变形为球形芽，球形芽在颈部分裂成囊泡。为了诱导膜弯曲，蛋白质外壳使用基本工具，包括两亲性螺旋和凹形蛋白质表面，并利用细胞膜的整体性质，如内质网和顺式高尔基体中的松散脂质包装以及质膜胞质小叶中阴离子脂质的丰度。蛋白质支架，膜曲率传感器和微调反应，如GTP水解允许这些工具的空间和时间组织，使蛋白质涂层自组织分子机器。由于生物膜通常粘附在细胞骨架上，因此蛋白质外壳的功能与膜界面处的其他大的重塑事件相关联。
Protein coats deform lipid membranes into spherical buds, which undergo fission at the neck to become vesicles. To induce membrane curvature, protein coats use basic tools including amphipathic helices and concave protein surfaces, and take advantage of the bulk properties of cellular membranes, such as loose lipid packing in the endoplasmic reticulum and cis-Golgi and the abundance of anionic lipids in the cytosolic leaflet of the plasma membrane. Protein scaffolds, sensors of membrane curvature and finely tuned reactions such as GTP hydrolysis permit the spatial and temporal organization of these tools, making protein coats self-organized molecular machines. Because biological membranes generally adhere to a cytoskeleton, the functioning of protein coats is coupled to other large remodeling events at the membrane interface.