Influence of interstitial bone microcracks on strain-induced fluid flow
Influence of interstitial bone microcracks on strain-induced fluid flow
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DOI：
10.1007/s10237-011-0287-1
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发表时间：
2011-12-01
影响因子：
3.5
通讯作者：
Naili, Salah
中科院分区：
文献类型：
--
作者：
Vu-Hieu Nguyen;Lemaire, Thibault;Naili, Salah
众所周知，微裂纹作为骨重建的刺激因素，启动破骨细胞的吸收和成骨细胞的新骨形成。此外，微裂纹可能会改变骨组织中的流体流动和对流传输。本文提出了一种定量评估应变诱导的间质流体速度在骨间质骨组织中存在微裂纹的情况下的发展。基于Biot理论，在低频范围内建立了一个孔弹性模型来研究裂纹骨组织的流体力学行为。有限元结果表明，间质骨组织中微裂纹的存在可能会显著降低相邻骨组织内的流体速度。骨骼内的这种液体非活跃区可以覆盖其表面的10%。因此，骨力学敏感细胞的流体环境被局部改变。
It is well known that microcracks act as a stimulus for bone remodelling, initiating resorption by osteoclasts and new bone formation by osteoblasts. Moreover, microcracks are likely to alter the fluid flow and convective transport through the bone tissue. This paper proposes a quantitative evaluation of the strain-induced interstitial fluid velocities developing in osteons in presence of a microcrack in the interstitial bone tissue. Based on Biot theory in the low-frequency range, a poroelastic model is carried out to study the hydro-mechanical behaviour of cracked osteonal tissue. The finite element results show that the presence of a microcrack in the interstitial osteonal tissue may drastically reduce the fluid velocity inside the neighbouring osteons. This fluid inactive zone inside osteons can cover up to 10% of their surface. Consequently, the fluid environment of bone mechano-sensitive cells is locally modified.