PROPAGATION OF INTERICTAL EPILEPTIC ACTIVITY IN TEMPORAL-LOBE EPILEPSY
PROPAGATION OF INTERICTAL EPILEPTIC ACTIVITY IN TEMPORAL-LOBE EPILEPSY
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DOI：
10.1212/wnl.45.1.118
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发表时间：
1995-01-01
期刊：
影响因子：
9.9
通讯作者：
LUDERS, H
中科院分区：
文献类型：
--
作者：
BAUMGARTNER, C;LINDINGER, G;LUDERS, H
我们用密集头皮电极和蝶骨电极记录了4例颞叶癫痫患者的发作间期棘波。我们使用多偶极子模型来研究癫痫棘波复合体背后的神经源的数量、三维脑内位置、时间活动和功能关系。在所有患者中，我们发现两个重要的来源产生发作间期尖峰，在空间和时间上都有相当大的重叠。源1位于近中底颞叶，在同侧蝶骨电极产生有限的负性，在头顶产生广泛的正性。源2可归因于外侧颞叶新皮层，并与同侧颞叶电极的相对有限的负性和对侧半球的更广泛的正性相关。源在空间上分离良好，它们之间的平均距离为45 mm。这两个来源的时间活动表现出类似的双相模式，与近中源领先的横向源约40毫秒，这表明传播的发作间期癫痫活动的近中基底侧颞叶。
We recorded interictal spikes with closely spaced scalp electrodes and sphenoidal electrodes in four patients with temporal lobe epilepsy. We used multiple dipole modeling to study the number, three-dimensional intracerebral location, time activity, and functional relationship of the neuronal sources underlying the epileptic spike complexes. In all patients, we found two significant sources generating the interictal spikes which showed considerable overlap in both space and time. Source 1 was located in the mesiobasal temporal lobe and generated a restricted negativity at the ipsilateral sphenoidal electrode and a widespread positivity over the vertex. Source 2 could be attributed to the lateral temporal neocortex and was associated with a relatively restricted negativity at the ipsilateral temporal electrodes and a more widespread positivity over the contralateral hemisphere. The sources were well separated in space, with an average distance of 45 mm between them. The time activities of both sources showed similar biphasic patterns, with the mesial source leading the lateral source by approximately 40 msec, suggesting propagation of interictal epileptic activity from the mesiobasal to the lateral temporal lobe.