Analysis of V beta 17a expression in new mouse strains bearing the V beta a haplotype.
Analysis of V beta 17a expression in new mouse strains bearing the V beta a haplotype.
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DOI：
10.1084/jem.169.5.1533
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发表时间：
1989-05-01
期刊：
影响因子：
--
通讯作者：
Marrack P
中科院分区：
文献类型：
--
作者：
Kappler JW;Kushnir E;Marrack P
A set of new mouse strains were produced that carry the V beta a haplotype of the TCR-alpha/beta and any of a number of different H-2 haplotypes on backgrounds derived from related C57BL, C57L, and C57BR mice. Study of V beta 17a expression in these mice confirms the association between the presence of IE and the deletion of V beta 17a+ T cells. A second H-2 gene causing deletion of V beta 17a+ T cells was mapped in these mice to the K end of H-2k, and H-2 influences on the level of selection of CD4+ V beta 17a+ T cells were indicated.
