SEX-DIFFERENCES IN RENAL HEMODYNAMICS IN RATS
SEX-DIFFERENCES IN RENAL HEMODYNAMICS IN RATS
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DOI：
10.1152/ajprenal.1988.254.2.f223
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发表时间：
1988-02-01
影响因子：
--
通讯作者：
BAYLIS, C
中科院分区：
文献类型：
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作者：
MUNGER, K;BAYLIS, C
这些研究旨在研究在对照条件下和对两种不同环氧合酶抑制剂反应时肾血流动力学的性别差异。在麻醉下对雄性、雌性和卵巢切除（OVX）大鼠以及不同品系的清醒、长期插管雄性和雌性大鼠的单独组进行研究。在对照期，在环氧合酶抑制前，雄性肾脏相对于雌性血管舒张。由于雄性和雌性大鼠每个肾脏的肾小球数量相同，因此雌性大鼠每个肾小球的总血管阻力显著大于雄性大鼠。在麻醉的完整雌性大鼠中，环氧合酶抑制引起单肾单位肾小球滤过率、肾小球血浆流速、肾小球滤过率和肾血浆流量显著增加，而传入和传出小动脉阻力和肾血管阻力下降。相比之下，麻醉的雄性和OVX雌性大鼠对环氧合酶抑制没有表现出肾脏血流动力学反应。在没有麻醉和近期手术的情况下，完整清醒的雌性大鼠与清醒的雄性大鼠的反应相似，均未显示对环氧合酶抑制的任何反应。这些数据表明，在基线肾血流动力学和肾对环氧合酶抑制的反应方面存在功能性性别差异，后者通过手术应激揭示。
These studies were designed to investigate sex differences in renal hemodynamics under control conditions and in response to two different cyclooxygenase inhibitors. Studies were performed under anesthesia in males, females, and ovariectomized (OVX) rats and in separate groups of conscious, chronically catheterized male and female rats of a different strain. In the control periods, before cyclooxygenase inhibition, the male kidney was vasodilated relative to the female. Because male and female rats have the same number of glomeruli per kidney, the total vascular resistance per glomerulus is substantially greater in females than males. Cyclooxygenase inhibition in the anesthetized intact female rat produced significant increases in single-nephron glomerular filtration rate, glomerular plasma flow rate, glomerular filtration rate, and renal plasma flow, whereas afferent and efferent arteriolar resistances and renal vascular resistance fell. In contrast, anesthetized male and OVX female rats showed no renal hemodynamic response to cyclooxygenase inhibition. In the absence of anesthesia and recent surgery, intact awake female rats responded similarly to conscious male rats in that neither showed any response to cyclooxygenase inhibition. These data suggest a functional sex difference in both baseline renal hemodynamics and the renal response to cyclooxygenase inhibition, the latter unveiled by surgical stress.