Moderate alcohol consumption lowers risk factors for cardiovascular disease in postmenopausal women fed a controlled diet
Moderate alcohol consumption lowers risk factors for cardiovascular disease in postmenopausal women fed a controlled diet
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DOI：
10.1093/ajcn/75.3.593
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发表时间：
2002-03-01
影响因子：
7.1
通讯作者：
Taylor, PR
中科院分区：
文献类型：
--
作者：
Baer, DJ;Judd, JT;Taylor, PR
背景：适量饮酒(1-2杯/d)可能通过改善血脂状况来降低绝经后妇女患心血管疾病的风险。目的：我们测量了适量饮酒对绝经后妇女血脂和脂蛋白的影响。设计：51名绝经后妇女采用随机交叉设计，每天摄入0(对照组)、15(1杯)和30(2)g酒精(酒精)，每组8wk。对照组提供的能量分别约为蛋白质、碳水化合物和脂肪的15%、53%和32%。结果：与对照组相比，每天饮酒15a后，血浆低密度脂蛋白胆固醇由3.45降至3.34 mmol/L(P=0.04)，三酰甘油由1.43降至1.34 mmol/L(P=0.05)。当饮酒量由15 g/d增加至30g/d时，上述两种脂类均无明显下降。高密度脂蛋白胆固醇在饮酒15g/d后升高不明显，从1.40增至1.43 mm ol/L，30g/d升高至1.48 mm o l/L(P=0.02)。与对照饮食前相比，饮酒30g后载脂蛋白A-I显著升高，载脂蛋白B显著降低。结论：绝经后妇女饮酒15~30g/d可明显改善血脂水平，降低心血管疾病风险。每天饮酒15克后，血浆低密度脂蛋白和三酰甘油浓度有所改善；每天饮酒30克后，血浆高密度脂蛋白胆固醇才有所改善。
Background: Moderate alcohol consumption (1-2 drinks/d) may decrease cardiovascular disease risk in postmenopausal women by improving lipid profiles.Objective: We measured the effect of moderate alcohol consumption on lipids and lipoproteins in postmenopausal women.Design: Postmenopausal women (n = 51) consumed 0 (control), 15 (1 drink), and 30 (2 drinks) g alcohol (ethanol)/d for 8 wk each as part of a controlled diet in a randomized crossover design. The control diet provided approximate to 15%, 53%, and 32% of energy from protein, carbohydrate, and fat, respectively. The energy provided from alcohol in the 15- and 30-g alcohol diets was replaced with energy from carbohydrate.Results: Compared with concentrations after the control diet, plasma LDL cholesterol decreased from 3.45 to 3.34 mmol/L (P = 0.04) and triacylglycerol from 1.43 to 1.34 mmol/L (P = 0,05) after 15 a alcohol/d. There were no additional significant decreases in either lipid after an increase in alcohol intake from 15 to 30 g/d. Compared with concentrations after the control diet, plasma HDL cholesterol increased nonsignificantly from 1.40 to 1.43 mmol/L after 15 g alcohol/d but increased to 1.48 mmol/L after 30 g alcohol/d (P = 0.02). Apolipoprotein A-I increased significantly and apolipoprotein B decreased significantly after 30 g alcoholld relative to the concentration after the control diet.Conclusions: Consumption of 15-30 g alcohol/d by postmenopausal women apparently decreases cardiovascular disease risk by improving lipid profiles. Plasma LDL-cholesterol and triacylglycerol concentrations improve after 15 g alcohol/d; plasma HDL cholesterol improves only after 30 g alcohol/d.