Properties of TiO2-polyacrylic acid dispersions with potential for molecular recognition
Properties of TiO2-polyacrylic acid dispersions with potential for molecular recognition
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DOI：
10.1016/j.colsurfb.2007.12.018
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发表时间：
2008-06-15
影响因子：
5.8
通讯作者：
Sonezaki, Shuji
中科院分区：
文献类型：
--
作者：
Kanehira, Koki;Banzai, Toshiaki;Sonezaki, Shuji
将二氧化钛(TiO2)/聚丙烯酸（PAA） （TiO2/PAA）纳米粒子在二甲基甲酰胺（DMF）中混合，然后热处理，形成TiO2/PAA粒子。TEM和颗粒分析表明，所得颗粒尺寸分布较窄。胶体非常稳定，在较宽的pH范围（3-9）或高盐浓度下均未观察到聚集现象。PAA的残羧酸可以通过EDC/NHS活化修饰，与蛋白质形成酰胺键。将抗体附着在杂交纳米颗粒上，并通过表面等离子体共振监测其与抗原的特异性结合。结果表明，TiO2/PAA纳米颗粒作为光催化体系的基础组分具有潜在的底物选择性。(C) 2008 Elsevier B.V.版权所有
Titanium dioxide (TiO2)/polyacrylic acid (PAA) (TiO2/PAA) particles were formed by mixing PAA and an acidic solution of TiO2 nanoparticles in dimethylformamide (DMF) followed by heat treatment. TEM and particle analysis showed that the resulting particles had a narrow size distribution. The colloid was very stable and aggregation was not observed over a wide pH range (3-9) or at high salt concentration. The residual carboxylic acid of PAA could be modified via EDC/NHS activation to form an amide bond with a protein. An antibody was attached to the hybrid nanoparticle and specific binding to antigen was monitored by surface plasmon resonance. The results suggest that TiO2/PAA nanoparticles are candidates as the base component of a photocatalytic system with potential for substrate selectivity. (C) 2008 Elsevier B.V. All rights reserved.