Cellular immunity and immunopathology in autoimmune Addison's disease
Cellular immunity and immunopathology in autoimmune Addison's disease
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DOI：
10.1016/j.mce.2010.12.015
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发表时间：
2011-04-10
影响因子：
4.1
通讯作者：
Husebye, Eystein S.
中科院分区：
文献类型：
--
作者：
Bratland, Eirik;Husebye, Eystein S.
自身免疫性肾上腺皮质功能衰竭或阿狄森病是一种典型的器官特异性自身免疫性疾病。与自身免疫性内分泌疾病有关。阿狄森氏病只能在一定程度上进行治疗，替代疗法是唯一的治疗选择。不幸的是，现有的治疗不能恢复生理激素水平和生物节律。治疗和预防自身免疫性阿狄森病的关键在于提高我们对诱发因素，疾病进展机制以及肾上腺抗原与免疫系统效应细胞和分子之间相互作用的理解。本文就T细胞和细胞免疫在自身免疫性Addison病发病机制中的作用作一综述。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Autoimmune adrenocortical failure, or Addison's disease, is a prototypical organ-specific autoimmune disorder. In common with related autoimmune endocrinopathies. Addison's disease is only manageable to a certain extent with replacement therapy being the only treatment option. Unfortunately, the available therapy does not restore the physiological hormone levels and biorhythm. The key to progress in treating and preventing autoimmune Addison's disease lies in improving our understanding of the predisposing factors, the mechanisms responsible for the progression of the disease, and the interactions between adrenal antigens and effector cells and molecules of the immune system. The aim of the present review is to summarize the current knowledge on the role of T cells and cellular immunity in the pathogenesis of autoimmune Addison's disease. (C) 2010 Elsevier Ireland Ltd. All rights reserved.