Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis
Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis
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DOI：
10.1016/j.clim.2011.01.013
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发表时间：
2011-06-01
影响因子：
8.6
通讯作者：
Filaci, Gilberto
中科院分区：
文献类型：
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作者：
Fenoglio, Daniela;Battaglia, Florinda;Filaci, Gilberto
这项研究的目的是了解系统性硬化症(SSC)患者TH17和Treg细胞亚群的关系。对36例SSC患者Th17和Treg细胞亚群的表型和功能进行了分析。与健康对照组相比，SSc患者外周血中Th17细胞浓度升高，与疾病类型或阶段无关。用多克隆刺激或白色念珠菌抗原刺激PBMC后，SSC患者的Th17T细胞克隆率明显高于对照组，提示SSC患者的免疫应答向Th17细胞的生成/扩增倾斜。在Treg亚群中，SSC患者外周血中CD8+CD28-Treg亚群和CD4+CD25+Treg亚群均有数量和质量上的变化。总而言之，这些数据强调了SSC患者Th17和Treg细胞亚群之间存在不平衡的比率。(C)2011 Elsevier Inc.保留所有权利。
Aim of the study has been to understand the relationship between TH17 and Treg cell subsets in patients affected with systemic sclerosis (SSc). Phenotypes and functions of Th17 and Treg cell subsets were analyzed in a series of 36 SSc patients. Th17 cell concentration in the peripheral blood was found to be increased in SSc patients with respect to healthy controls independently from type or stage of disease. After PBMC stimulation with a polyclonal stimulus or Candida albicans antigens the frequency of Th17 T cell clones was significantly higher in SSc patients with respect to controls suggesting the skewing of immune response in SSc patients toward Th17 cell generation/expansion. Concerning the Treg compartment, both CD4+CD25+ and CD8+CD28- Treg subsets showed quantitative and qualitative alteration in the peripheral blood of SSc patients. Collectively, these data highlight the existence of an imbalanced ratio between Th17 and Treg cell subsets in SSc patients. (C) 2011 Elsevier Inc. All rights reserved.