Diverse functions of Hedgehog signaling in formation and physiology of steroidogenic organs.
Diverse functions of Hedgehog signaling in formation and physiology of steroidogenic organs.
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DOI:
10.1002/mrd.21174
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发表时间:
2010-06
影响因子:
2.5
通讯作者:
Yao, Humphrey Hung-Chang
中科院分区:
文献类型:
--
作者:
Huang, Chen-Che Jeff;Yao, Humphrey Hung-Chang
Adrenal, testis, and ovary are steroidogenic organs derived from a common primordium that consists of steroidogenic factor 1 (SF1)-positive precursor cells. SF1 not only defines the steroidogenic lineages in these organs but also controls their differentiation. Recent evidence implicates the Hedgehog (Hh) signaling pathway as a downstream regulator of SF1 in the appearance of steroidogenic cells in these organs. The Hh signaling pathway serves as a common crosstalk component, yet has evolved diverse functions in the expansion and differentiation of the steroidogenic cells in a tissue-specific manner. The purpose of this review is to compare and contrast the different roles of Hh signaling in these three organs during development.
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通讯作者:
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DOI:
10.1002/ajmg.1320070111
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期刊:
AMERICAN JOURNAL OF MEDICAL GENETICS
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