Diverse functions of Hedgehog signaling in formation and physiology of steroidogenic organs.

Diverse functions of Hedgehog signaling in formation and physiology of steroidogenic organs.
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DOI:
10.1002/mrd.21174
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发表时间:
2010-06
影响因子:
2.5
通讯作者:
Yao, Humphrey Hung-Chang
Yao, Humphrey Hung-Chang
中科院分区:
生物学3区
文献类型:
--
作者:
Huang, Chen-Che Jeff;Yao, Humphrey Hung-Chang

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肾上腺、睾丸和卵巢是类固醇生成器官,它们来源于由类固醇生成因子1(SF1)阳性前体细胞组成的共同原基。SF1不仅定义了这些器官中的类固醇生成谱系,而且还控制它们的分化。最近的证据表明,刺猬(Hh)信号通路作为SF1的下游调节器在这些器官中的类固醇生成细胞的外观。Hh信号通路作为一个共同的串扰组件,但已经演变成不同的功能,在类固醇激素细胞的扩增和分化中的组织特异性的方式。本文旨在比较和对比Hh信号在这三个器官发育过程中的不同作用。
Adrenal, testis, and ovary are steroidogenic organs derived from a common primordium that consists of steroidogenic factor 1 (SF1)-positive precursor cells. SF1 not only defines the steroidogenic lineages in these organs but also controls their differentiation. Recent evidence implicates the Hedgehog (Hh) signaling pathway as a downstream regulator of SF1 in the appearance of steroidogenic cells in these organs. The Hh signaling pathway serves as a common crosstalk component, yet has evolved diverse functions in the expansion and differentiation of the steroidogenic cells in a tissue-specific manner. The purpose of this review is to compare and contrast the different roles of Hh signaling in these three organs during development.
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