Evaluation of autologous adipose-derived mesenchymal stem cell therapy in focal chondral defects of the knee: a pilot case series
Evaluation of autologous adipose-derived mesenchymal stem cell therapy in focal chondral defects of the knee: a pilot case series
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DOI：
10.2217/rme-2020-0027
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发表时间：
2020-07-31
影响因子：
2.7
通讯作者：
Tenen, Abi
中科院分区：
文献类型：
--
作者：
Freitag, Julien;Shah, Kiran;Tenen, Abi
目的：评估自体脂肪间充质干细胞（ADMSC）治疗联合关节镜下磨损关节成形术治疗膝关节局灶性软骨缺损的安全性、疼痛、功能和结构改善情况。方法：8例膝关节局灶性全层软骨缺损患者接受关节镜下磨损关节成形术，术后关节内注射自体ADMSC（基线和6个月时为50 × 10（6）ADMSC）。临床结果采用数字疼痛评定量表、膝关节损伤和骨关节炎结果评分以及西安大略和麦克马斯特大学骨关节炎指数进行评估。结构结果由磁共振成像确定。结果：在24个月内进行了评估，没有严重的不良事件发生。参与者观察到疼痛和功能的临床显著改善。磁共振成像分析显示，软骨再生与T2映射值相媲美的透明软骨。结论：关节镜下磨损关节成形术结合关节内ADMSC治疗结果再现疼痛，功能和结构的改善与透明样软骨的再生。
Aim:To evaluate the safety, pain, functional and structural improvements after autologous adipose-derived mesenchymal stem cell (ADMSC) therapy in combination with arthroscopic abrasion arthroplasty in focal chondral defects of the knee.Methods:Eight patients with a focal full thickness chondral defect of the knee underwent arthroscopic abrasion arthroplasty followed by postoperative intra-articular injections of autologous ADMSCs (50 x 10(6)ADMSCs at baseline and 6 months). Clinical outcome was assessed using numeric pain rating scale, Knee Injury and Osteoarthritis Outcome Score and the Western Ontario and McMaster Universities Osteoarthritis Index. Structural outcome was determined by magnetic resonance imaging. Outcome was assessed over 24 months.Results:No serious adverse events occurred. Participants observed clinically significant improvement in pain and function. Magnetic resonance imaging analysis showed cartilage regeneration with T2 mapping values comparable to hyaline cartilage.Conclusion:Arthroscopic abrasion arthroplasty in combination with intra-articular ADMSC therapy results in reproducible pain, functional and structural improvements with regeneration of hyaline-like cartilage.