Spontaneous fos expression in the suprachiasmatic nucleus of young and old mice.
Spontaneous fos expression in the suprachiasmatic nucleus of young and old mice.
复制标题
年轻和年老小鼠视交叉上核的自发 fos 表达。
DOI：
10.1016/j.neurobiolaging.2004.08.008
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发表时间：
2005
影响因子：
4.2
通讯作者：
Pang,KevinCH
中科院分区：
文献类型：
--
作者：
Miller,JonathanP;McAuley,JDevin;Pang,KevinCH
衰老加速小鼠(SAMP8)是一种衰老的动物模型，早在7个月大的时候就表现出一系列的昼夜节律紊乱。本研究通过检测c-Fos免疫组织化学染色，探讨与年龄相关的昼夜节律变化的生理学基础。2、7和12月龄的SAMP8在昼夜节律时间(CTs)2和14检测了SCN“核心”和“外壳”的细胞活动。与先前的研究一致，我们观察到在CT2的细胞活动水平高于CT14，并且在SCN的“外壳”中的活动水平高于在SCN的“核心”中。然而，年龄对SCN的“核心”和“外壳”中的细胞活动模式没有影响。这些结果是在当前关于啮齿动物SCN中自发和光诱导的c-Fos表达的研究背景下讨论的。
The senescence-accelerated mouse (SAMP8) is an animal model of aging that displays an array of circadian rhythm disruptions as early as 7 months of age. The present study explored the physiological basis for age-related changes in circadian rhythms by measuring c-Fos immunostaining. Cellular activity in the SCN “core” and “shell” was examined for 2-, 7-, and 12-month-old SAMP8 at circadian times (CTs) 2 and 14. Consistent with previous studies in rats, we observed higher levels of cellular activity at CT2 than at CT14, and higher levels of activity in the “shell” than in the “core” of the SCN. However, there was no effect of age on the pattern of cellular activity in either the “core” or the “shell” of the SCN. These results are discussed in the context of current research on spontaneous and light-induced c-Fos expression in the SCN of rodents.