C-type natriuretic peptide: the endothelial component of the natriuretic peptide system.
C-type natriuretic peptide: the endothelial component of the natriuretic peptide system.
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DOI：
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发表时间：
1998
影响因子：
3
通讯作者：
H. H. Chen-H.;J. Burnett
中科院分区：
文献类型：
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作者：
H. H. Chen-H.;J. Burnett
C型利钠肽（CNP）是一种由22个氨基酸组成的肽，在结构上与心房利钠肽（ANP）和脑利钠肽（BNP）相关，但在遗传学上不同。ANP和BNP是鸟苷酸环化酶偶联受体（NPR-A受体）的配体，而CNP是NPR-B受体的特异性配体。除了通过NPR-C受体清除外，CNP还受到胞外酶中性内肽酶24.11（NEP）的降解，NEP广泛分布于肾脏、肺、心脏和内皮细胞中。尽管最初在猪脑中发现CNP免疫反应性，但已在人血管内皮细胞、血浆和肾脏中发现CNP免疫反应性。CNP具有强效的全身性心血管作用，包括心脏充盈压和心输出量降低（继发于血管舒张和静脉回流减少），但肾脏作用极小。与ANP不同，CNP是一种选择性内皮非依赖性静脉扩张剂。然而，它也是一种有效的冠状血管扩张剂。内皮细胞表达CNP基因、血管平滑肌细胞（VSMC）上存在CNP受体以及CNP对VSMC的抗有丝分裂作用表明CNP由内皮产生，并作用于邻近的VSMC，作为自分泌/旁分泌内皮源性血管调节系统。
C-type natriuretic peptide (CNP) is a 22-amino-acid peptide, structurally related to but genetically distinct from atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Whereas ANP and BNP are ligands for a guanylyl cyclase-coupled receptor, the NPR-A receptor, CNP is a specific ligand for the NPR-B receptor. In addition to clearance by the NPR-C receptor, CNP is subject to degradation by the ectoenzyme neutral endopeptidase 24.11 (NEP), which is widely distributed in the kidney, lung, heart, and endothelial cells. Although initially identified in porcine brain, CNP immunoreactivity has been found in human vascular endothelial cells, plasma, and kidney. CNP has potent systemic cardiovascular actions, which include reductions in cardiac filling pressures and output, secondary to vasorelaxation and decreases in venous return, but has minimal renal actions. Unlike ANP, CNP is a selective endothelium-independent venodilator. However, it is also a potent coronary vasodilator. Expression of the CNP gene by the endothelial cells, the presence of CNP receptors on vascular smooth muscle cells (VSMCs), and the antimitogenic effect of CNP on VSMCs suggest that CNP is produced by the endothelium and acts on adjacent VSMCs serving as an autocrine/paracrine endothelium-derived vasoregulatory system.