ARTERIAL BLOOD-PRESSURE AND HEART-RATE INDUCED BY GLUCAGON-LIKE PEPTIDE-1-(7-36) AMIDE IN RATS
ARTERIAL BLOOD-PRESSURE AND HEART-RATE INDUCED BY GLUCAGON-LIKE PEPTIDE-1-(7-36) AMIDE IN RATS
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DOI：
10.1152/ajpendo.1994.266.3.e459
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发表时间：
1994-03-01
影响因子：
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通讯作者：
BLAZQUEZ, E
中科院分区：
文献类型：
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作者：
BARRAGAN, JM;RODRIGUEZ, RE;BLAZQUEZ, E
胰高血糖素样肽-1-(7-36)酰胺对大鼠动脉血压和心率的影响。点。[j] .中国生物医学工程。中国生物医学工程学报，29(3):459- 466,1994。-本研究旨在确定胰高血糖素样肽（GLP）对动脉血压和心率的影响。虽然胰高血糖素的影响很小，而GLP-1-(1-37)产生了适度的收缩压和舒张压升高，但GLP-1-(7-36)酰胺诱导了这两个参数的最大升高。当多肽剂量增加时，收缩压、舒张压和心率值增加。相比之下，GLP-2没有改变动脉血压或心率值。为了确定GLP-1-(7-36)酰胺的作用是否通过猫回声胺介导，在给药前用利血平、心得安或酚妥拉明对大鼠进行预处理。在这三个实验组中，GLP-1-(7-36)酰胺使平均动脉血压和心率升高到与未预处理大鼠相同甚至更高的水平。这些发现表明，GLP-1-(7-36)酰胺显著增加动脉血压和心率，这些作用不是通过儿茶酚胺介导的。
Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E459-E466, 1994. - This study was designed to determine the effects of glucagon-like peptides (GLP) on arterial blood pressure and heart rate. Although glucagon caused a minimal effect and GLP-1-(1-37) produced a moderate increase of both systolic and diastolic blood pressure, GLP-1-(7-36) amide induced the greatest increases in both parameters. Systolic and diastolic blood pressure and heart rate values increased when doses of the peptides were increased. By contrast, GLP-2 did not modify either arterial blood pressure or heart rate values. To determine whether the effects of GLP-1-(7-36) amide were mediated through cat echolamines, the rats were pretreated with reserpine, propranolol, or phentolamine before administration of the peptide. In these three experimental groups, GLP-1-(7-36) amide increases mean arterial blood pressure and heart rate to the same level or even greater than that observed in nonpretreated rats. These findings indicate that GLP-1-(7-36) amide significantly increases arterial blood pressure and heart rate and that these effects are not mediated through catecholamines.