Component and functional mechanism of the ferrous iron acquisition system in gram-negative bacteria - A review
Component and functional mechanism of the ferrous iron acquisition system in gram-negative bacteria - A review
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DOI：
10.13343/j.cnki.wsxb.20150403
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Cheng, Anchun
中科院分区：
文献类型：
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作者：
Feng, Yan;Liu, Mafeng;Cheng, Anchun
几乎所有的细菌都需要铁来生长和生存。在好氧环境中，细菌几乎不能直接利用铁离子。但亚铁主要存在于宿主胃肠道中。可溶性亚铁[Fe(II)]通过膜转运蛋白直接进入胞质，然后通过亚铁转运系统进入细胞质。大多数革兰氏阴性菌通过FeO系统吸收亚铁。大肠杆菌中的FeO转运系统由feoA、feoB和feoC基因组成。除FeO运输系统外，YFE运输系统、EFe运输系统和SIT运输系统也参与了黑铁的运输。本文就革兰氏阴性菌中FeO系统的组成及作用机制进行综述，以期为其他细菌亚铁转运机制的研究提供参考。
Nearly all bacteria require iron for growth and survival. In aerobic environment, ferric iron almost cannot be utilized directly by bacteria. But ferrous iron is mainly existing in the host gastrointestinal. Soluble ferrous iron [Fe(II)] is imported directly via membrane transporters into periplasmic, then ferrous iron is imported via ferrous iron transport systems into cytoplasm. Most of gram-negative bacteria uptake ferrous iron by Feo system. The Feo transport system in Escherichia coli consists of the feoA, feoB, and feoC genes. In addition to the Feo transport system, the Yfe transport system and the Efe transport system and the Sit transport system are involved in the transport of ferrous iron. In this review, we described the component and functional mechanism of Feo system in gram-negative bacteria, to provide reference for studying other bacteria ferrous iron transport mechanism.