Clinicopathological characteristics of signet ring cell carcinoma of the stomach
Clinicopathological characteristics of signet ring cell carcinoma of the stomach
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DOI：
10.1111/j.1445-1433.2004.03268.x
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发表时间：
2004-12-01
影响因子：
1.7
通讯作者：
Lee, JH
中科院分区：
文献类型：
--
作者：
Kim, DY;Park, YK;Lee, JH
背景：胃印戒细胞（SRC）癌的特点是预后差，有可能浸润胃壁，尽管比较具有和不具有SRC特征的癌的生存研究结果不一致。本研究比较了胃非印戒细胞癌和胃非印戒细胞癌的临床病理特征和预后。方法：回顾1980年1月至1999年12月在全南大学附属医院外科手术治疗的2358例胃癌患者的临床资料。204例（8.7%）为SRC癌，2154例为NSRC癌。结果：SRC与NSRC患者在平均年龄、平均肿瘤大小、浸润深度、肝脏及区域淋巴结转移发生率、肿瘤分期、治愈率等方面存在显著差异。SRC癌和NSRC患者在性别、部位或腹膜传播方面无统计学差异。SRC胃癌的早期胃癌患病率（46.1%）高于NSRC胃癌（21.7%）。所有SRC癌患者的总5年生存率为60.2%，而NSRC患者的总5年生存率为48.9% (P
Background: Signet ring cell (SRC) carcinoma of the stomach is characterized by its poor prognosis and potential to infiltrate the wall of stomach, although survival studies comparing carcinomas with and without SRC features have yielded inconsistent results. This study compared the clinicopathological features and prognosis of patients with SRC carcinoma with those with non-signet ring cell carcinoma of the stomach (NSRC).Methods: We reviewed the records of 2358 patients diagnosed with gastric carcinoma who were treated surgically between January 1980 and December 1999 at the Department of Surgery, Chonnam National University Hospital. There were 204 patients (8.7%) with SRC carcinoma as compared to 2154 with NSRC.Results: Significant differences were noted in the mean patient age, mean tumour size, depth of invasion, prevalence of hepatic and regional lymph node metastases, tumour stage, and curability between the patients with SRC histology and NSRC. There were no statistically significant differences in patient gender, location, or peritoneal dissemination between patients with SRC carcinoma and NSRC. SRC carcinoma of the stomach had a higher prevalence of early gastric carcinoma (46.1%) than NSRC (21.7%). The overall 5-year survival of all the patients with SRC carcinoma was 60.2% as compared with 48.9% for the patients with NSRC (P