Thiazole antibiotic thiostrepton synergize with bortezomib to induce apoptosis in cancer cells.
Thiazole antibiotic thiostrepton synergize with bortezomib to induce apoptosis in cancer cells.
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DOI：
10.1371/journal.pone.0017110
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发表时间：
2011-02-18
期刊：
影响因子：
3.7
通讯作者：
Gartel AL
中科院分区：
文献类型：
--
作者：
Pandit B;Gartel AL
Thiazole antibiotic, thiostrepton was recently identified as proteasome inhibitor. We investigated the therapeutic potential of the combination of thiostrepton and proteasome inhibitor bortezomib (Velcade) on various human tumor cell lines. Combination of sub-lethal concentrations of thiostrepton and bortezomib induced potent apoptosis and inhibition of long-term colony formation in a wide variety of human cancer cell lines. The synergistic relationship between thiostrepton and bortezomib combination was also quantitatively demonstrated by calculating their combination index values that were much lower than 1 in all studied cell lines. The synergy between these drugs was based on their proteasome inhibitory activities, because thiostrepton modification, thiostrepton methyl ester, which did not have intact quinaldic acid ring and did not inhibit proteasome activity failed to demonstrate any synergy in combination with bortezomib.
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影响因子：
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通讯作者：
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DOI：
10.1002/pros.21116
发表时间：
2010-06-01
期刊：
The Prostate
影响因子：
--
作者：
Pandit B;Gartel AL
通讯作者：
Gartel AL
影响因子：
16.6
作者：
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通讯作者：
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