A prospective study of self-reported sleep duration and incident diabetes in women
A prospective study of self-reported sleep duration and incident diabetes in women
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DOI：
10.2337/diacare.26.2.380
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发表时间：
2003-02-01
期刊：
影响因子：
16.2
通讯作者：
Hu, FB
中科院分区：
文献类型：
--
作者：
Ayas, NT;White, DP;Hu, FB
短期睡眠限制会导致葡萄糖耐量受损。为了测试习惯性睡眠不足是否会增加患糖尿病的风险，我们研究了70,026名参加护士健康研究的女性，她们在基线时没有糖尿病，并在1986年回答了一个关于每天睡眠时间的问题。受试者随访至1996年诊断糖尿病（1969例）。睡眠时间的长短与糖尿病诊断风险的增加有关。短睡眠者（每天睡眠少于或等于5小时）和长睡眠者（每天睡眠大于或等于9小时）的相对风险（rr）分别为1.57 （95% CI 1.28-1.92）和1.47（1.19-1.80）。在调整BMI和各种混杂因素后，短睡眠者的RR没有显著增加（1.18[0.96-1.44]），但长睡眠者的RR仍略有增加（1.29[1.05-1.59]）。然后，我们仅使用有症状的病例（n = 1187）进行了类似的分析。短睡眠者（1.34[1.04-1.72]）和长睡眠者（1.35[1.04-1.75]）有症状糖尿病的调整后风险比均有轻微升高。我们的数据表明，自我报告的睡眠时间减少与糖尿病诊断之间的联系可能是由于BMI的混淆，或者睡眠限制可能通过体重增加来调节其对糖尿病的影响。睡眠不足可能是发展有症状糖尿病的独立危险因素。
Short-term sleep restriction results in impaired glucose tolerance. To test whether habitually short sleep duration increases the risk of developing diabetes, we studied a cohort of 70,026 women enrolled in the Nurses Health Study, without diabetes at baseline, and who responded to a question about daily sleep duration in 1986. Subjects were followed until 1996 for the diagnosis of diabetes (1,969 cases). Long and short sleep durations were associated with an increased risk of diabetes diagnosis. The relative risks (RRs) for short (slept less than or equal to5 h per day) and long (slept greater than or equal to9 h per day) sleepers were 1.57 (95% CI 1.28-1.92) and 1.47 (1.19-1.80), respectively. After adjustment for BMI and a variety of confounders, the RR was not significantly increased for short sleepers (1.18 [0.96-1.44]) but remained modestly increased for long sleepers (1.29 [1.05-1.59]). We then performed a similar analysis using only symptomatic cases (n = 1,187). Adjusted RRs for symptomatic diabetes were modestly elevated in both short (1.34 [1.04-1.72]) and long (1.35 [1.04-1.75]) sleepers. Our data suggest that the association between a reduced self-reported sleep duration and diabetes diagnosis could be due to confounding by BMI, or sleep restriction may mediate its effects on diabetes through weight gain. Sleep restriction may be an independent risk factor for developing symptomatic diabetes.