Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients
Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients
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DOI：
10.3892/etm.2012.511
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发表时间：
2012-06-01
影响因子：
2.7
通讯作者：
Date, Hiroshi
中科院分区：
文献类型：
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作者：
Kobayashi, Masashi;Huang, Cheng-Long;Date, Hiroshi
恶性胸膜间皮瘤是一种侵袭性的胸部肿瘤，预后差。我们对MPM瘤内Wnt 1、Wnt 2B和Wnt 5A的表达进行了全面的临床研究。对107名MPM患者进行了调查。免疫组化检测肿瘤内Wnt 1、Wnt 2B、Wnt 5A、survivin、c-Myc的表达及Ki-67增殖指数。TUNEL法检测细胞凋亡指数。在107例MPM中，23例（21.5%）为Wnt 1高表达肿瘤，72例（67.3%）为Wnt 2B高表达肿瘤，54例（50.5%）为Wnt 5A高表达肿瘤。Wnt表达水平之间无相关性。Wnt 2B阳性肿瘤的百分比显著高于其他Wnt（p
Malignant pleural mesothelioma (MPM) is an aggressive thoracic tumor with a poor prognosis. We performed a comprehensive clinical study on the intratumoral expression of Wnt1, Wnt2B and Wnt5A in MPM. One hundred and seven MPM patients were investigated. Immunohistochemistry was performed to evaluate the intratumoral expression of Wnt1, Wnt2B, Wnt5A, survivin and c-Myc, and the Ki-67 proliferation index. The apoptotic index was evaluated by the TUNEL method. Among the 107 MPMs, 23 MPMs (21.5%) were Wnt1-high tumors, 72 MPMs (67.3%) were Wnt2B-high tumors and 54 MPMs (50.5%) were Wnt5A-high tumors. There was no correlation among the levels of Wnt expression. The percentage of Wnt2B-positive tumors was significantly higher compared to that of the other Wnts (p