Metastasis-associated in colon cancer-1 in gastric cancer: Beyond metastasis
Metastasis-associated in colon cancer-1 in gastric cancer: Beyond metastasis
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DOI：
10.3748/wjg.v22.i29.6629
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发表时间：
2016-08-07
影响因子：
4.3
通讯作者：
Liao, Wang-Jun
中科院分区：
文献类型：
--
作者：
Wu, Zhen-Zhen;Chen, Li-Shan;Liao, Wang-Jun
结肠癌转移相关基因-1（MACC 1）是一种在结肠癌中首次发现的癌基因。MACC 1的上游和下游形成了一个微妙的调控网络，支持其在癌症中的致瘤作用。MACC 1在许多癌症中具有多种功能。在胃癌（GC）中，MACC 1已被证明参与肿瘤发生和肿瘤进展。MACC 1过表达对GC患者的临床结局有不利影响。关于MACC 1在GC中的作用机制，研究表明其促进上皮向间质转化并加速癌症转移。MACC 1除了转移外还参与GC的许多标志。MACC 1通过TWIST 1/2促进血管生成拟态（VM），VM增加肿瘤血液供应，这是肿瘤进展所必需的。MACC 1还通过上调VEGF-C/D的细胞外分泌促进GC淋巴管生成，表明MACC 1可能是GC淋巴播散的重要参与者。此外，MACC 1通过增强瓦尔堡效应支持代谢应激下的GC生长。总之，MACC 1参与了GC细胞内外的多种生物学过程，使其成为肿瘤微环境的重要介质。
Metastasis-associated in colon cancer-1 (MACC1) is an oncogene that was first identified in colon cancer. The upstream and downstream of MACC1 form a delicate regulatory network that supports its tumorigenic role in cancers. Multiple functions of MACC1 have been discovered in many cancers. In gastric cancer (GC), MACC1 has been shown to be involved in oncogenesis and tumor progression. MACC1 overexpression adversely affects the clinical outcomes of GC patients. Regarding the mechanism of action of MACC1 in GC, studies have shown that it promotes the epithelial-to-mesenchymal transition and accelerates cancer metastasis. MACC1 is involved in many hallmarks of GC in addition to metastasis. MACC1 promotes vasculogenic mimicry (VM) via TWIST1/2, and VM increases the tumor blood supply, which is necessary for tumor progression. MACC1 also facilitates GC lymphangiogenesis by upregulating extracellular secretion of VEGF-C/D, indicating that MACC1 may be an important player in GC lymphatic dissemination. Additionally, MACC1 supports GC growth under metabolic stress by enhancing the Warburg effect. In conclusion, MACC1 participates in multiple biological processes inside and outside of GC cells, making it an important mediator of the tumor microenvironment.